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dc.contributor.authorSoejarto, D.D.
dc.contributor.authorGyllenhaal, C.
dc.contributor.authorKadushin, M.R.
dc.contributor.authorSouthavong, B.
dc.contributor.authorSydara, K.
dc.contributor.authorBouamanivong, S.
dc.contributor.authorXaiveu, M.
dc.contributor.authorZhang, H.-J.
dc.contributor.authorFranzblau, S.G.
dc.contributor.authorTan, Ghee T.
dc.contributor.authorPezzuto, J.M.
dc.contributor.authorRiley, M.C.
dc.contributor.authorElkington, B.G.
dc.contributor.authorWaller, D.P.
dc.date.accessioned2013-09-12T15:59:18Z
dc.date.available2013-12-06T22:58:28Z
dc.date.issued2012-01
dc.identifier.bibliographicCitationSoejarto, D. D., Gyllenhaal, C., Kadushin, M. R., Southavong, B., Sydara, K., Bouamanivong, S., Xaiveu, M., Zhang, H. J., Franzblau, S. G., Tan, G. T., Pezzuto, J. M., Riley, M. C., Elkington, B. G., & Waller, D. P. 2012. An ethnobotanical survey of medicinal plants of Laos toward the discovery of bioactive compounds as potential candidates for pharmaceutical development. Pharmaceutical Biology, 50(1): 42-60. DOI: 10.3109/13880209.2011.619700en_US
dc.identifier.issn1388-0209
dc.identifier.otherDOI: 10.3109/13880209.2011.619700
dc.identifier.urihttp://hdl.handle.net/10027/10099
dc.descriptionPost print version of article may differ from published version. The definitive version is available through Informa Healthcare at DOI: 10.3109/13880209.2011.619700en_US
dc.description.abstractContext: An ethnobotany-based approach in the selection of raw plant materials to study was implemented. Objective: To acquire raw plant materials using ethnobotanical field interviews as starting point to discover new bioactive compounds from medicinal plants of the Lao People’s Democratic Republic. Methods: Using semi-structured field interviews with healers in the Lao PDR, plant samples were collected, extracted, and bio-assayed to detect bioactivity against cancer, HIV/AIDS, TB, malaria. Plant species demonstrating activity were recollected and the extracts subjected to a bioassay-guided isolation protocol to isolate and identify the active compounds. Results: Field interviews with 118 healers in 15 of 17 provinces of Lao PDR yielded 753 collections [573 species] with 955 plant samples. Of these 955, 50 extracts demonstrated activity in the anticancer, 10 in the anti-HIV, 30 in the anti-TB, and 52 in the anti-malarial assay. Recollection of actives followed by bioassay-guided isolation processes yielded a series of new and known in vitro-active anticancer and antimalarial compounds from 5 species. Discussion: Laos has a rich biodiversity, harboring an estimated 8,000-11,000 species of plants. In a country highly dependent on traditional medicine for its primary health care, this rich plant diversity serves as a major source of their medication. Conclusion: Ethnobotanical survey has demonstrated the richness of plant-based traditional medicine of Lao PDR, taxonomically and therapeutically. Biological assays of extracts of half of the 955 samples followed by in-depth studies of a number of actives have yielded a series of new bioactive compounds against the diseases of cancer and malaria.en_US
dc.description.sponsorshipThis research was supported by NIH Grants 1-UO1-TW-001015-1 and 2-UO1-TW001015-06, International Cooperative Biodiversity Groups (ICBG), through funds from the National Institutes of Health, National Science Foundation, and the US Department of Agriculture Foreign Agricultural Service.en_US
dc.language.isoen_USen_US
dc.publisherInforma Healthcareen_US
dc.subjectLaosen_US
dc.subjectbiodiversityen_US
dc.subjectethnobotanical surveyen_US
dc.subjectinterview methodsen_US
dc.subjectmedicinal plantsen_US
dc.subjectbioactive compoundsen_US
dc.subjectcanceren_US
dc.subjectHIV/AIDSen_US
dc.subjecttuberculosisen_US
dc.subjectmalariaen_US
dc.titleAn ethnobotanical survey of medicinal plants of Laos toward the discovery of bioactive compounds as potential candidates for pharmaceutical developmenten_US
dc.typeArticleen_US


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