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dc.contributor.authorWang, Yong
dc.contributor.authorMendoza-Elias, Joshua E.
dc.contributor.authorQi, Meirigeng
dc.contributor.authorHarvat, Tricia A.
dc.contributor.authorAhn, Sang Joon
dc.contributor.authorLee, Dongyoung
dc.contributor.authorGutierrez, Diana
dc.contributor.authorJeon, Hyojin
dc.contributor.authorPaushter, Daniel
dc.contributor.authorOberholzer, José
dc.date.accessioned2013-10-24T17:58:52Z
dc.date.available2013-10-24T17:58:52Z
dc.date.issued2012
dc.identifier.bibliographicCitationWang, Y., J. E. Mendoza-Elias, et al. (2012). "Implication of Mitochondrial Cytoprotection in Human Islet Isolation and Transplantation." Biochemistry Research International . 2012: 395974. doi:10.1155/2012/395974en_US
dc.identifier.issn2090-2255
dc.identifier.other10.1155/2012/395974
dc.identifier.urihttp://hdl.handle.net/10027/10113
dc.descriptionCopyright © 2012 Yong Wang et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The original version is available through Hindawi Publishing Corporation at DOI: 10.1155/2012/395974en_US
dc.description.abstractIslet transplantation is a promising therapy for type 1 diabetes mellitus; however, success rates in achieving both short- and longterm insulin independence are not consistent, due in part to inconsistent islet quality and quantity caused by the complex nature and multistep process of islet isolation and transplantation. Since the introduction of the Edmonton Protocol in 2000, more attention has been placed on preserving mitochondrial function as increasing evidences suggest that impaired mitochondrial integrity can adversely affect clinical outcomes. Some recent studies have demonstrated that it is possible to achieve islet cytoprotection by maintaining mitochondrial function and subsequently to improve islet transplantation outcomes. However, the benefits of mitoprotection in many cases are controversial and the underlying mechanisms are unclear. This article summarizes the recent progress associated with mitochondrial cytoprotection in each step of the islet isolation and transplantation process, as well as islet potency and viability assays based on the measurement of mitochondrial integrity. In addition, we briefly discuss immunosuppression side effects on islet graft function and how transplant site selection affects islet engraftment and clinical outcomes.en_US
dc.language.isoen_USen_US
dc.publisherHindawi Publishing Corporationen_US
dc.titleImplication of Mitochondrial Cytoprotection in Human Islet Isolation and Transplantationen_US
dc.typeArticleen_US


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