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dc.contributor.authorGyllenhaal, C.
dc.contributor.authorKadushin, M. R.
dc.contributor.authorSouthavong, B.
dc.contributor.authorSydara, K.
dc.contributor.authorBouamanivong, S.
dc.contributor.authorXaiveu, M.
dc.contributor.authorXuan, L. T.
dc.contributor.authorHiep, N. T.
dc.contributor.authorHung, N. V.
dc.contributor.authorLoc, P. K.
dc.contributor.authorDac, L. X.
dc.contributor.authorBich, T. Q.
dc.contributor.authorCuong, N. M.
dc.contributor.authorLy, H. M.
dc.contributor.authorZhang, H. J.
dc.contributor.authorFranzblau, S. G.
dc.contributor.authorXie, H.
dc.contributor.authorRiley, M. C.
dc.contributor.authorElkington, B. G.
dc.contributor.authorNguyen, H. T.
dc.contributor.authorWaller, D. P.
dc.contributor.authorMa, C. Y.
dc.contributor.authorTamez, P.
dc.contributor.authorTan, G. T.
dc.contributor.authorPezzuto, J. M.
dc.contributor.authorSoejarto, D. D.
dc.date.accessioned2013-10-25T14:39:11Z
dc.date.available2013-12-06T22:58:09Z
dc.date.issued2012-01
dc.identifier.bibliographicCitationGyllenhaal, C., Kadushin, M. R., Southavong, B., Sydara, K., Bouamanivong, S., Xaiveu, M., Xuan, L. T., Hiep, N. T., Hung, N. V., Loc, P. K., Dac, L. X., Bich, T. Q., Cuong, N. M., Ly, H. M., Zhang, H. J., Franzblau, S. G., Xie, H., Riley, M. C., Elkington, B. G., Nguyen, H. T., Waller, D. P., Ma, C. Y., Tamez, P., Tan, G. T., Pezzuto, J. M., & Soejarto, D. D. 2012. Ethnobotanical approach versus random approach in the search for new bioactive compounds: Support of a hypothesis. Pharmaceutical Biology , 50(1): 30-41. DOI: 10.3109/13880209.2011.634424en_US
dc.identifier.issn1388-0209
dc.identifier.otherDOI: 10.3109/13880209.2011.634424
dc.identifier.urihttp://hdl.handle.net/10027/10317
dc.descriptionPost print version of article may differ from published version. The definitive version is available through Pharmaceutical Biology © 2012 Informa Healthcare. DOI: 10.3109/13880209.2011.634424en_US
dc.description.abstractContext: Whether natural product drug discovery programs should rely on wild plants collected “randomly” from the natural environment, or whether they should also include plants collected on the basis of use in traditional medicine remains an open question. Objective: This study analyzes whether plants with ethnomedical uses from Vietnam and Laos have a higher hit rate in bioassay testing than plants collected from a national park in Vietnam with the goal of maximizing taxonomic diversity (“random” collection). Materials and Methods: All plants were extracted and subjected to bioassay in the same laboratories. Results of assays of plant collections and plant parts (samples) were scored as active or inactive based on whether any extracts had a positive result in a bioassay. Contingency tables were analyzed using chi-square statistics. Results: Random collections had a higher hit rate than ethnomedical collections, but for samples, ethnomedical plants were more likely to be active. Ethnomedical collections and samples had higher hit rates for tuberculosis, while samples, but not collections, had a higher hit rate for malaria. Little evidence was found to support an advantage for ethnomedical plants in HIV, chemoprevention and cancer bioassays. Plants whose ethnomedical uses directly correlated to a bioassay did not have a significantly higher hit rate than random plants. Discussion: Plants with ethnomedical uses generally had a higher rate of activity in some drug discovery bioassays, but the assays did not directly confirm specific uses. Conclusion: Ethnomedical uses may contribute to a higher rate of activity in drug discovery screening.en_US
dc.description.sponsorshipThe Vietnam-Laos ICBG is supported by grants administered by the Fogarty International Center, U.S. National Institutes of Health (NIH), with funding supplied by NIH, National Science Foundation and the United States Department of Agriculture, as follows: 1 UO1 TW001015-01; 2 UO1 TW001015-06; 3 UO1 TW 001015-10S1; 3 UO1 TW001015-10S2; 2 UO1 TW001015-11A1.en_US
dc.language.isoen_USen_US
dc.publisherInforma Healthcareen_US
dc.subjectTraditional medicineen_US
dc.subjectDrug discoveryen_US
dc.subjectScreeningen_US
dc.subjectVietnamen_US
dc.subjectTuberculosisen_US
dc.subjectMalariaen_US
dc.subjectHIVen_US
dc.titleEthnobotanical approach versus random approach in the search for new bioactive compounds: support of a hypothesisen_US
dc.typeArticleen_US


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