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dc.contributor.authorKang, Hahk-Soo
dc.contributor.authorKrunic, Aleksej
dc.contributor.authorOrjala, Jimmy
dc.date.accessioned2013-10-25T16:53:34Z
dc.date.available2013-10-25T16:53:34Z
dc.date.issued2012-07-11
dc.identifier.bibliographicCitationKang HS, Krunic A, Orjala J. Sanctolide A, a 14-membered PK-NRP hybrid macrolide from the cultured cyanobacterium Oscillatoria sancta (SAG 74.79). Tetrahedron Letters. 2012 Jul 11;53(28):3563-3567.DOI: 10.1016/j.tetlet.2012.04.136en_US
dc.identifier.issn0040-4039
dc.identifier.urihttp://hdl.handle.net/10027/10323
dc.descriptionNOTICE: This is the author’s version of a work that was accepted for publication in Tetrahedron Letters. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. A definitive version was subsequently published in Tetrahedron Letters, Vol 53, Issue 28, 11 July 2012 DOI:10.1016/j.tetlet.2012.04.136en_US
dc.description.abstractSanctolide A (1), a 14-membered polyketide-nonribosomal peptide (PK-NRP) hybrid macrolide, was isolated from the cultured cyanobacterium Oscillatoria sancta (SAG 74.79). The planar structure was determined using various spectroscopic techniques including HRESIMS, and 1D and 2D NMR analyses. The relative configuration was assigned by J-based configurational analysis in combination with NOE correlations. The absolute configuration was determined by Mosher ester and enantioselective HPLC analyses. The structure of sanctolide A (1) features a rare N-methyl enamide and a 2-hydroxyisovaleric acid, which are incorporated to form a 14-membered macrolide ring structure, comprising a new type of cyanobacterial macrolides derived from a PKS-NRPS hybrid biosynthetic pathway.en_US
dc.description.sponsorshipThis research was supported by PO1 CA125066 from NCI/NIH.en_US
dc.language.isoen_USen_US
dc.publisherElsevieren_US
dc.subjectcyanobacteriaen_US
dc.subjectOscillatoria sanctaen_US
dc.subject14-membered macrolideen_US
dc.subjectPK-NRP hybriden_US
dc.subjectbrine shrimp toxicityen_US
dc.titleSanctolide A, a 14-membered PK-NRP hybrid macrolide from the cultured cyanobacterium Oscillatoria sancta (SAG 74.79)en_US
dc.typeArticleen_US


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