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    Modulation of C1-Inhibitor and Plasma Kallikrein Activities by Type IV Collagen

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    Date
    2012
    Author
    Ravindran, Sriram
    Schapira, Marc
    Patston, Philip A.
    Publisher
    Hindawi Publishing Corporation
    Metadata
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    Abstract
    The contact system of coagulation can be activated when in contact with biomaterials. As collagen is being tested in novel biomaterials in this study, we have investigated how type IV collagen affects plasma kallikrein and C1-inhibitor. Firstly, we showed C1-inhibitor binds to type IV collagen with a Kd of 0.86 muM. The effects of type IV collagen on plasma kallikrein, factor XIIa, and beta-factor XIIa activity and on C1-inhibitor function were determined. Factor XIIa rapidly lost activity in the presence of type IV collagen, whereas plasma kallikrein and beta-factor XIIa were more stable. The rate of inhibition of plasma kallikrein by C1-inhibitor was decreased by type IV collagen in a dose-dependent manner. These studies could be relevant to the properties of biomaterials, which contain collagen, and should be considered in the testing for biocompatibility
    Subject
    affect
    article
    Biomaterial
    Chicago
    Coagulation
    Collagen
    Illinois
    INHIBITION
    Medicine
    MODULATION
    oral
    Plasma
    Science
    SYSTEM
    Universities
    Type
    Article
    Date available in INDIGO
    2013-11-01T16:00:36Z
    URI
    http://hdl.handle.net/10027/10390
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    • Publications - Oral Biology

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