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    Insulin Resistance and Cognition Among HIV-Infected and HIV-Uninfected Adult Women: The Women’s Interagency HIV Study

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    Date
    2012-05
    Author
    Valcour, Victor
    Maki, Pauline
    Bacchetti, Peter
    Anastos, Kathryn
    Crystal, Howard
    Young, Mary
    Mack, Wendy J.
    Cohen, Mardge
    Golub, Elizabeth T.
    Tien, Phyllis C.
    Publisher
    Mary Ann Liebert
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    Abstract
    Cognitive impairment remains prevalent in the era of combination antiretroviral therapy (cART) and may be partially due to comorbidities. We postulated that insulin resistance (IR) is negatively associated with cognitive performance. We completed a cross-sectional analysis among 1547 (1201 HIV+ ) women enrolled in the Women’s Interagency HIV Study (WIHS). We evaluated the association of IR with cognitive measures among all WIHS women with concurrent fasting bloods and cognitive testing [Trails A, Trails B, and Symbol Digit Modalities Test (SDMT)] using multiple linear regression models. A smaller subgroup also completed the Stroop test (n = 1036). IR was estimated using the Homeostasis Model Assessment (HOMA). Higher HOMA was associated with poorer performance on the SDMT, Stroop Color-Naming (SCN) trial, and Stroop interference trial, but remained statistically significant only for the SCN in models adjusting for important factors [b = 3.78 s (95% CI: 0.48–7.08), p = 0.025, for highest vs. lowest quartile of HOMA]. HIV status did not appear to substantially impact the relationship of HOMA with SCN. There was a small but statistically significant association of HOMA and reduced neuropsychological performance on the SCN test in this cohort of women.
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    Article
    Date available in INDIGO
    2013-11-01T16:09:56Z
    URI
    http://hdl.handle.net/10027/10391
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    • Publications - Psychiatry

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