Show simple item record

dc.contributor.authorKang, Hahk-Soo
dc.contributor.authorSturdy, Megan
dc.contributor.authorKrunic, Aleksej
dc.contributor.authorKim, Hyunjung
dc.contributor.authorShen, Qi
dc.contributor.authorSwanson, Steven M.
dc.contributor.authorOrjala, Jimmy
dc.date.accessioned2013-11-01T16:38:22Z
dc.date.available2013-11-01T16:38:22Z
dc.date.issued2012-10
dc.identifier.bibliographicCitationKang HS, Sturdy M, Krunic A, Kim H, Shen Q, Swanson SM, Orjala J. Minutissamides E-L, antiproliferative cyclic lipodecapeptides from the cultured freshwater cyanobacterium cf. Anabaena sp. Bioorganic and Medicinal Chemistry. 2012 Oct 15;20(20) DOI: 10.1016/j.bmc.2012.08.017en_US
dc.identifier.issn1464-3391
dc.identifier.urihttp://hdl.handle.net/10027/10393
dc.descriptionNOTICE: This is the author’s version of a work that was accepted for publication in Bioorganic and Medicinal Chemistry . Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. A definitive version was subsequently published in Bioorganic and Medicinal Chemistry, [Vol 20, Issue 20, 2012] DOI: 10.1016/j.bmc.2012.08.017.en_US
dc.description.abstractThe extract of UIC 10035, a strain obtained from a sample collected near the town of Homestead, south Florida, showed antiproliferative activity against MDA-MB-435 cells. Bioassay-guided fractionation led to the isolation of a series of cyclic lipodecapeptides, named minutissamides E - L (1 – 8). The planar structures were determined by analysis of HRESIMS, tandem MS, and 1D and 2D NMR data, and the stereoconfigurations were assigned by LC-MS analysis of the Marfey’s derivatives after acid hydrolysis. Minutissamides E - L (1 – 8) exhibited antiproliferative activity against MDA-MB-435 cells with IC50 values ranging between 1 and 10 μM. The structures of minutissamides E - L (1 – 8) were closely related with those of the previously reported lipopeptides, puwainaphycins A - E and minutissamides A - D, characterized by the presence of a lipophilic β-amino acid and three non-standard amino acids NMeAsn, OMeThr and Dhb (α,β-dehydro-α-aminobutyric acid). The strain UIC 10035 was designated as cf. Anabaena sp. on the basis of morphological and 16S rRNA gene sequence analyses.en_US
dc.description.sponsorshipThis research was supported by PO1 CA125066 from NCI/NIH.en_US
dc.language.isoen_USen_US
dc.publisherElsevieren_US
dc.subjectCyanobacteriaen_US
dc.subjectAnabaenaen_US
dc.subjectCyclic lipopeptidesen_US
dc.subjectMDA-MB-435en_US
dc.subjectAntiproliferative activityen_US
dc.titleMinutissamides E-L, antiproliferative cyclic lipodecapeptides from the cultured freshwater cyanobacterium cf. Anabaena sp.en_US
dc.typeArticleen_US


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record