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dc.contributor.authorMotl, Robert W.
dc.contributor.authorSuh, Yoojin
dc.contributor.authorBalantrapu, Swathi
dc.contributor.authorSandroff, Brian M.
dc.contributor.authorSosnoff, Jacob J.
dc.contributor.authorPula, John
dc.contributor.authorGoldman, Myla D.
dc.contributor.authorFernhall, Bo
dc.date.accessioned2013-11-08T15:55:22Z
dc.date.available2013-11-08T15:55:22Z
dc.date.issued2012-03
dc.identifier.bibliographicCitationMotl RW, Suh Y, Balantrapu S, Sandroff BM, Sosnoff JJ, Pula J, Goldman MD, Fernhall B. Evidence for the different physiological significance of the 6- and 2-minute walk tests in multiple sclerosis. BMC Neurol. 2012 Mar 1;12:6. DOI: 10.1186/1471-2377-12-6en_US
dc.identifier.issn1471-2377
dc.identifier.urihttp://hdl.handle.net/10027/10423
dc.description© 2012 Motl et al; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.en_US
dc.description.abstractBackground: Researchers have recently advocated for the 2-minute walk (2MW) as an alternative for the 6-minute walk (6MW) to assess long distance ambulation in persons with multiple sclerosis (MS). This recommendation has not been based on physiological considerations such as the rate of oxygen consumption (V·O2) over the 6MW range. Objective: This study examined the pattern of change in V·O2 over the range of the 6MW in a large sample of persons with MS who varied as a function of disability status. Method: Ninety-five persons with clinically-definite MS underwent a neurological examination for generating an Expanded Disability Status Scale (EDSS) score, and then completion of the 6MW protocol while wearing a portable metabolic unit and an accelerometer. Results: There was a time main effect on V·O2 during the 6MW (p = .0001) such that V·O2 increased significantly every 30 seconds over the first 3 minutes of the 6MW, and then remained stable over the second 3 minutes of the 6MW. This occurred despite no change in cadence across the 6MW (p = .84). Conclusions: The pattern of change in V·O2 indicates that there are different metabolic systems providing energy for ambulation during the 6MW in MS subjects and steady state aerobic metabolism is reached during the last 3 minutes of the 6MW. By extension, the first 3 minutes would represent a test of mixed aerobic and anaerobic work, whereas the second 3 minutes would represent a test of aerobic work during walking.en_US
dc.language.isoen_USen_US
dc.publisherBioMed Centralen_US
dc.subjectAmbulationen_US
dc.subjectEnergy expenditureen_US
dc.subjectMultiple sclerosisen_US
dc.subjectOxygen consumptionen_US
dc.subjectWalkingen_US
dc.titleEvidence for the different physiological significance of the 6- and 2-minute walk tests in multiple sclerosisen_US
dc.typeArticleen_US


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