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dc.contributor.authorPini, Maria
dc.contributor.authorRhodes, Davina H.
dc.contributor.authorCastellanos, Karla J.
dc.contributor.authorCabay, Robert J.
dc.contributor.authorGrady, Eileen F.
dc.contributor.authorFantuzzi, Giamila
dc.date.accessioned2013-11-08T17:28:35Z
dc.date.available2013-11-08T17:28:35Z
dc.date.issued2012-07
dc.identifier.bibliographicCitationPini, M., D. H. Rhodes, et al. (2012). "Rosiglitazone improves survival and hastens recovery from pancreatic inflammation in obese mice." PLoS One 7(7): e40944. DOI: 10.1371/journal.pone.0040944en_US
dc.identifier.issn1932-6203
dc.identifier.other10.1371/journal.pone.0040944
dc.identifier.urihttp://hdl.handle.net/10027/10432
dc.description© 2012 Pini et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. The original version is available through Public Library of Science at DOI: 10.1371/journal.pone.0040944.en_US
dc.description.abstractObesity increases severity of acute pancreatitis (AP) by unclear mechanisms. We investigated the effect of the PPAR-gamma agonist rosiglitazone (RGZ, 0.01% in the diet) on severity of AP induced by administration of IL-12+ IL-18 in male C57BL6 mice fed a low fat (LFD) or high fat diet (HFD), under the hypothesis that RGZ would reduce disease severity in HFD-fed obese animals. In both LFD and HFD mice without AP, RGZ significantly increased body weight and % fat mass, with significant upregulation of adiponectin and suppression of erythropoiesis. In HFD mice with AP, RGZ significantly increased survival and hastened recovery from pancreatic inflammation, as evaluated by significantly improved pancreatic histology, reduced saponification of visceral adipose tissue and less severe suppression of erythropoiesis at Day 7 post-AP. This was associated with significantly lower circulating and pancreas-associated levels of IL-6, Galectin-3, osteopontin and TIMP-1 in HFD + RGZ mice, particularly at Day 7 post-AP. In LFD mice with AP, RGZ significantly worsened the degree of intrapancreatic acinar and fat necrosis as well as visceral fat saponification, without affecting other parameters of disease severity or inflammation. Induction of AP lead to major suppression of adiponectin levels at Day 7 in both HFD and HFD + RGZ mice. In conclusion, RGZ prevents development of severe AP in obese mice even though it significantly increases adiposity, indicating that obesity can be dissociated from AP severity by improving the metabolic and inflammatory milieu. However, RGZ worsens selective parameters of AP severity in LFD mice.en_US
dc.description.sponsorshipThis study was supported by National Institues of Health grants DK083328 to GF and DK080787-03S3 to EFG.en_US
dc.language.isoen_USen_US
dc.publisherPublic Library of Scienceen_US
dc.titleRosiglitazone Improves Survival and Hastens Recovery from Pancreatic Inflammation in Obese Miceen_US
dc.typeArticleen_US


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