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dc.contributor.authorJamadar, Rhoda
dc.contributor.authorWinters, Mary
dc.contributor.authorMaki, Pauline
dc.date.accessioned2013-11-15T16:13:22Z
dc.date.available2013-11-15T16:13:22Z
dc.date.issued2012-03
dc.identifier.bibliographicCitationJamadar, R. J. Winters, M. J. Maki, P. M. (2012). "Cognitive changes associated with ADT: a review of the literature." Asian Journal of Andrology 14(2): 232-238. doi: 10.1038/aja.2011.107en_US
dc.identifier.issn1745-7262
dc.identifier.urihttp://hdl.handle.net/10027/10500
dc.descriptionPost print version of article may differ from published version. The definitive version is available through Nature Publishing Group at DOI:10.1038/aja.2011.107en_US
dc.description.abstractThe use of androgen deprivation therapy (ADT) has increased since the early 1990s after early detection efforts and greater use of the PSA test. Although ADT is associated with favorable clinical outcomes, ADT has been associated with an increased risk for cardiovascular disease, increased serum cholesterol, triglycerides, insulin resistance, body mass index, and fat body mass. Here we review findings from 11 clinical studies examining the effects of ADT on cognition as measured by standardized tests in cognitive domains such as verbal and spatial memory. Most of these studies have important limitations, including small sample sizes, suboptimal control groups, and baseline group differences in confounding factors. Despite these limitations, the best designed studies, those that comparing patients on ADT to healthy controls, generally suggest that spatial memory might be especially sensitive to the effects of ADT. Critically, to date there is only one study involving random assignment of ADT versus close clinical observation. That study revealed a decrease in verbal memory with ADT but was limited in sample size and did not include a measure of spatial memory. A recent observational study revealed no substantial evidence of cognitive impairment with ADT, even in the domain of verbal memory. Like the randomized study, however, this large observational study lacked a measure of spatial memory. Overall, the studies with the best controls suggests a potential negative impact of ADT on spatial memory, and perhaps verbal memory, and a need for continued investigation of the impact of ADT on cognition, particularly in these two cognitive domains.en_US
dc.language.isoen_USen_US
dc.publisherNature Publishing Groupen_US
dc.subjectAndrogen Antagonistsen_US
dc.subjectCognition Disordersen_US
dc.subjectEstradiolen_US
dc.subjectProstatic Neoplasms/drug therapy*en_US
dc.titleCognitive Changes Associated with ADT: A Review of the Literatureen_US
dc.typeArticleen_US


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