|dc.contributor.author||Fierro, Michelle A.||
|dc.contributor.author||Winston, Nicola J.||
|dc.identifier.bibliographicCitation||Scoccia B, Demir H, Kang Y, Fierro MA, Winston NJ. In vitro fertilization pregnancy rates in levothyroxine-treated women with hypothyroidism compared to women without thyroid dysfunction disorders. Thyroid. 2012 Jun;22(6):631-6. doi: 10.1089/thy.2011.0343.||en_US
|dc.description||This is a copy of an article published in the Thyroid © 2012 Copyright Mary Ann Liebert, Inc.; Thyroid is available online at: http://www.liebertonline.com.||en_US
|dc.description.abstract||Background: Untreated hypothyroidism can lead to ovulatory dysfunction resulting in oligo-amenorrhea.
Treatment with levothyroxine can reverse such dysfunction and thus should improve fertility. The purpose of
this retrospective study was to assess whether in vitro fertilization (IVF) pregnancy rates differ in levothyroxinetreated
women with hypothyroidism compared to women without thyroid dysfunction/disorders.
Methods: Treated hypothyroid and euthyroid women undergoing IVF at an academic IVF center were studied
after Institutional Review Board approval. Women with hypothyroidism were treated with levothyroxine 0.025–
0.15 mg/day for at least 3 months to maintain baseline thyrotropin (TSH) levels of 0.35–4.0 lU/mL prior to
commencing IVF treatment (HYPO-Rx group). Causes of infertility were similar in both groups with the exception
of male factor, which was more common in the HYPO-Rx group. The main outcomes studied were
implantation rate, clinical pregnancy rate, clinical miscarriage rate, and live birth rate.
Results: We reviewed the first IVF retrieval cycle performed on 240 women aged 37 years or less during the
period January 2003 to December 2007. Women with treated hypothyroidism (n = 21) had significantly less
implantation, clinical pregnancy, and live birth rates than euthyroid women (n = 219).
Conclusions: We conclude that, despite levothyroxine treatment, women with hypothyroidism have a significantly
decreased chance of achieving a pregnancy following IVF compared to euthyroid patients. A larger
prospective study is necessary to assess confounding variables, confirm these findings, and determine the
optimal level of TSH prior to and during controlled ovarian hyperstimulation for IVF.||en_US
|dc.description.sponsorship||This project was supported by the University of Illinois at
Chicago Center for Clinical Translational Science, Award
Number UL1RR029879, from the National Center for Research
|dc.publisher||Mary Ann Liebert||en_US
|dc.title||In Vitro Fertilization Pregnancy Rates
in Levothyroxine-Treated Women With Hypothyroidism
Compared to Women Without Thyroid Dysfunction Disorders||en_US