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dc.contributor.authorGong, Shi-qiang
dc.contributor.authorEpasinghe, Jeevani
dc.contributor.authorRueggeberg, Frederick A.
dc.contributor.authorNiu, Li-na
dc.contributor.authorMettenberg, Donald
dc.contributor.authorYiu, Cynthia K. Y.
dc.contributor.authorBlizzard, John D.
dc.contributor.authorWu, Christine D.
dc.contributor.authorMao, Jing
dc.contributor.authorDrisko, Connie L.
dc.contributor.authorPashley, David H.
dc.contributor.authorTay, Franklin R.
dc.date.accessioned2013-11-19T19:44:06Z
dc.date.available2013-11-19T19:44:06Z
dc.date.issued2012-08
dc.identifier.bibliographicCitationGong, S. Q. Epasinghe, J. Rueggeberg, F. A. Niu, L. N. Mettenberg, D. Yiu, C. K. Y. Blizzard, J. D. Wu, C. D. Mao, J. Drisko, C. L. Pashley, D. H. Tay, F. R..An ORMOSIL-Containing Orthodontic Acrylic Resin with Concomitant Improvements in Antimicrobial and Fracture Toughness Properties. PLoS One. 2012;7(8). DOI: 10.1371/journal.pone.0042355en_US
dc.identifier.issn1932-6203
dc.identifier.urihttp://hdl.handle.net/10027/10546
dc.description© 2012 Gong et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. The original version is available through Public Library of Science at DOI: 10.1371/journal.pone.0042355en_US
dc.description.abstractGlobal increase in patients seeking orthodontic treatment creates a demand for the use of acrylic resins in removable appliances and retainers. Orthodontic removable appliance wearers have a higher risk of oral infections that are caused by the formation of bacterial and fungal biofilms on the appliance surface. Here, we present the synthetic route for an antibacterial and antifungal organically-modified silicate (ORMOSIL) that has multiple methacryloloxy functionalities attached to a siloxane backbone (quaternary ammonium methacryloxy silicate, or QAMS). By dissolving the water-insoluble, rubbery ORMOSIL in methyl methacrylate, QAMS may be copolymerized with polymethyl methacrylate, and covalently incorporated in the pressure-processed acrylic resin. The latter demonstrated a predominantly contact-killing effect on Streptococcus mutans ATCC 36558 and Actinomyces naselundii ATCC 12104 biofilms, while inhibiting adhesion of Candida albicans ATCC 90028 on the acrylic surface. Apart from its favorable antimicrobial activities, QAMS-containing acrylic resins exhibited decreased water wettability and improved toughness, without adversely affecting the flexural strength and modulus, water sorption and solubility, when compared with QAMS-free acrylic resin. The covalently bound, antimicrobial orthodontic acrylic resin with improved toughness represents advancement over other experimental antimicrobial acrylic resin formulations, in its potential to simultaneously prevent oral infections during appliance wear, and improve the fracture resistance of those appliances.en_US
dc.description.sponsorshipThis work was supported by grant R01 DE015306-06 from NIDCR (PI. David Pashley) and the ERA award from Georgia Health Sciences University (PI. Franklin Tay).en_US
dc.language.isoen_USen_US
dc.publisherPublic Library of Scienceen_US
dc.titleAn ORMOSIL-Containing Orthodontic Acrylic Resin with Concomitant Improvements in Antimicrobial and Fracture Toughness Propertiesen_US
dc.typeArticleen_US


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