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dc.contributor.authorPetersen, Sarah C.
dc.contributor.authorWatson, Joseph D.
dc.contributor.authorRichmond, Janet E.
dc.contributor.authorSarov, Mihail
dc.contributor.authorWalthall, Walter W.
dc.contributor.authorMiller III, David M.
dc.date.accessioned2013-11-22T16:43:56Z
dc.date.available2013-11-22T16:43:56Z
dc.date.issued2011-10
dc.identifier.bibliographicCitationPetersen SC, Watson JD, Richmond JE, Sarov M, Walthall WW, Miller DM 3rd. A transcriptional program promotes remodeling of GABAergic synapses in Caenorhabditis elegans. Journal of Neuroscience. 2011 Oct 26;31(43):15362-75 doi: 10.1523/JNEUROSCI.3181-11.2011en_US
dc.identifier.issn1529-2401
dc.identifier.urihttp://hdl.handle.net/10027/10598
dc.descriptionThis is a copy of an article published in the Journal of Neuroscience © 2012 Society for Neuroscience. The final publication is available at http://www.jneurosci.org/doi: 10.1523/JNEUROSCI.3181-11.2011en_US
dc.description.abstractAlthough transcription factors are known to regulate synaptic plasticity, downstream genes that contribute to neural circuit remodeling are largely undefined. In Caenorhabditis elegans, GABAergic Dorsal D (DD) motor neuron synapses are relocated to new sites during larval development. This remodeling program is blocked in Ventral D (VD) GABAergic motor neurons by the COUP-TF (chicken ovalbumin upstream promoter transcription factor) homolog, UNC-55. We exploited this UNC-55 function to identify downstream synaptic remodeling genes that encode a diverse array of protein types including ion channels, cytoskeletal components, and transcription factors. We show that one of these targets, the Iroquois-like homeodomain protein, IRX-1, functions as a key regulator of remodeling in DD neurons. Our discovery of irx-1 as an unc-55-regulated target defines a transcriptional pathway that orchestrates an intricate synaptic remodeling program. Moreover, the well established roles of these conserved transcription factors in mammalian neural development suggest that a similar cascade may also control synaptic plasticity in more complex nervous systems.en_US
dc.description.sponsorshipThis work was supported by National Institutes of Health (NIH) Grants R21 MH077302 (D.M.M.), R01 NS26115 (D.M.M.), T32 GM08554 (S.C.P.), F31 NS063669 (S.C.P.), F31 NS049743 (J.D.W.), and R01 MH073156 (J.E.R.)en_US
dc.language.isoen_USen_US
dc.publisherSociety for Neuroscienceen_US
dc.titleA Transcriptional Program Promotes Remodeling of GABAergic Synapses in Caenorhabditis elegansen_US
dc.typeArticleen_US


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