Show simple item record

dc.contributor.authorDong, Xiao-Li
dc.contributor.authorZhao, Ming
dc.contributor.authorWong, Kwun-Kit
dc.contributor.authorChe, Chun-Tao
dc.contributor.authorWong, Man-Sau
dc.date.accessioned2013-12-02T17:57:00Z
dc.date.available2013-12-02T17:57:00Z
dc.date.issued2012-07
dc.identifier.bibliographicCitationDong XL, Zhao M, Wong KK, Che CT, Wong MS. Improvement of calcium balance by Fructus Ligustri Lucidi extract in mature female rats was associated with the induction of serum parathyroid hormone levels. British Journal of Nutrition. 2012;108(1):92-101. DOI: 10.1017/S0007114511005186en_US
dc.identifier.issn0007-1145
dc.identifier.urihttp://hdl.handle.net/10027/10714
dc.descriptionThis is a copy of an article published in the British Journal of Nutrition © 2012 Cambridge University Press. The final publication is available at http://journals.cambridge.org/action/displayJournal?jid=BJNen_US
dc.description.abstractFructus Ligustri Lucidi (FLL) is a commonly prescribed herb in many kidney-tonifying Traditional Chinese Medicinal formulae for the treatment of osteoporosis. The present study aimed to identify the active fractions in FLL and to characterise its effects on Ca balance, calciotropic hormone levels as well as bone properties in mature female rats fed diets containing different levels of Ca. In the present study, 4-month-old Sprague-Dawley female rats were treated with either FLL ethanol extract (EE), ethyl acetate-soluble fraction of EE (EAF), water-soluble fraction of EE (WF) or their vehicle for 12 weeks on a medium-Ca diet (MCD, 0.6% Ca, 0.65% P). Then, the Sprague Dawley female rats treated with WF or its vehicle for 12 weeks were fed diets containing different levels of dietary Ca (low-Ca diet (LCD), 0.1% Ca, 0.65% P; MCD; high-Ca diet (HCD), 1.2% Ca, 0.65% P). The results demonstrated that WF from EE but not EAF exerted a prominent effect on Ca balance by inhibiting urinary and faecal Ca excretion. WF significantly increased Ca balance in rats fed MCD or HCD with an associated increase in serum parathyroid hormone (PTH) levels. WF did not alter bone mineral density or bone mineral content of the tibia in all the rats fed with different levels of dietary Ca. In conclusion, WF was responsible for the positive actions of FLL on Ca absorption and balance. The regulation of Ca balance by WF might involve its action in stimulating PTH production in the mature female rats.en_US
dc.language.isoen_USen_US
dc.publisherCambridge University Pressen_US
dc.subjectFructus Ligustri Lucidien_US
dc.subjectCalcium balanceen_US
dc.subjectMature ratsen_US
dc.subjectDietary calciumen_US
dc.subjectParathyroid hormoneen_US
dc.titleImprovement of calcium balance by Fructus Ligustri Lucidi extract in mature female rats was associated with the induction of serum parathyroid hormone levelsen_US
dc.typeArticleen_US


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record