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dc.contributor.authorSundar, Jyotsna
dc.contributor.authorGnanasekar, Munirathinam
dc.date.accessioned2013-12-05T18:56:01Z
dc.date.available2013-12-05T18:56:01Z
dc.date.issued2013-05
dc.identifier.bibliographicCitationSundar J, Gnanasekar M. Can dehydroepiandrostenedione (DHEA) target PRL-3 to prevent colon cancer metastasis? Medical Hypotheses. 2013 May;80(5):595-7. doi: 10.1016/j.mehy.2013.01.033.en_US
dc.identifier.issn1532-2777
dc.identifier.urihttp://hdl.handle.net/10027/10819
dc.descriptionNOTICE: This is the author’s version of a work that was accepted for publication in Medical Hypotheses. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. A definitive version was subsequently published in Medical Hypotheses, [Vol 80, Issue 5, 2013] DOI: 10.1016/j.mehy.2013.01.033en_US
dc.description.abstractColorectal cancer (CRC) is a frequently diagnosed cancer and causing significant mortality in the patients. Metastasis caused by CRC is mainly responsible for this cancer-related deaths. Despite recent advancements in the treatment methods, prognosis remains poor. Therefore, effective treatment strategies need to be designed for successful management of this disease. Dehydroepiandrostenedione (DHEA), a 17-ketosteroid hormone produced by adrenal glands, gonads and including gastrointestinal tract is required for several physiological processes. Deregulation of DHEA levels leads to various disease conditions including cancer. In fact, several experimental studies strongly suggest that DHEA could be used as a chemopreventive agent against colon cancer. Prenlyation of certain membrane proteins such as phosphatase of regenerating liver-3 (PRL-3) is crucial for metastatic progression of colon cancer cells. The ability of DHEA to target prenylation pathway could be utilized to inhibit PRL-3 prenylation for successful prevention of CRC metastases. As DHEA is a widely consumed drug for various ailments, incorporation of DHEA in the treatment regimen may be beneficial to prevent or delay the occurrence of metastasis resulting from CRC.en_US
dc.description.sponsorshipStudy partly supported by University of Illinois Rockford Health Sciences Innovation in Education, Research and Community Project.en_US
dc.language.isoen_USen_US
dc.publisherElsevieren_US
dc.subjectDHEAen_US
dc.subjectPRL-3en_US
dc.subjectcolon canceren_US
dc.titleCan Dehydroepiandrostenedione (DHEA) target PRL-3 to prevent colon cancer metastasis?en_US
dc.typeArticleen_US


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