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dc.contributor.authorFriedman, Lee S.
dc.date.accessioned2013-12-05T19:08:31Z
dc.date.available2013-12-05T19:08:31Z
dc.date.issued2012-12
dc.identifier.bibliographicCitationFriedman LS. Dose--response relationship between in-hospital mortality and alcohol following acute injury. Alcohol. 2012 Dec;46(8):769-75. doi: 10.1016/j.alcohol.2012.08.006.en_US
dc.identifier.issn1873-6823
dc.identifier.urihttp://hdl.handle.net/10027/10821
dc.descriptionNOTICE: This is the author’s version of a work that was accepted for publication in Alcohol. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. A definitive version was subsequently published in Alcohol, [Vol 46, Issue 8, (2012)] DOI: 10.1016/j.alcohol.2012.08.006en_US
dc.description.abstractAlthough the relationship between alcohol and injury incidence is well researched, there continues to be dispute about the relationship between alcohol and mortality following an injury. Findings from past studies have varied primarily because of methodological issues and have failed to characterize the dose-response relationship. The main objective of this study was to evaluate the dose response relationship of in-hospital mortality and blood alcohol concentration (BAC). This study was a retrospective analysis of traumatic injuries occurring between 1995-2009 as reported by all level 1 and 2 trauma units in the State of Illinois. The study includes all patients with blood alcohol toxicological examination levels ranging from zero to 500 mg/dl (N=190,612). The Illinois trauma registry includes all patients sustaining traumatic injuries and admitted to a trauma center for > 12 hours. A total of 6,733 patients meeting the inclusion criteria died following admission. Patients that were dead on arrival and those that died during the initial assessment within the emergency room were excluded. In the adjusted multivariable model, a decrease in in-hospital mortality was strongly associated with an increase in blood alcohol concentration (adjusted OR = 0.83 per 100 mg/dl units change in BAC; CI95%: 0.80, 0.85; p<0.001). The direction of the dose response relationship was consistent across the stratified models, with the exception of patients suffering burns. The largest reduction of in-hospital case fatality rates by blood alcohol concentration was observed among patients suffering penetrating or severe injuries (Injury Severity Score >16). In the clinical setting, it is important to understand not only how to recognize intoxicated patients, but also how alcohol may affect the course of treatment. The consistency of the findings across the multivariable models indicates that blood alcohol concentration is strongly associated with lower in-hospital mortality among those that survive long enough to receive treatment in specialized trauma units.en_US
dc.language.isoen_USen_US
dc.publisherElsevier Massonen_US
dc.subjectalcoholen_US
dc.subjectethanolen_US
dc.subjectinjuryen_US
dc.subjectmortalityen_US
dc.subjectdose-responseen_US
dc.subjecttraumaen_US
dc.titleDose-Response Relationship Between In-Hospital Mortality and Alcohol Following Acute Injuryen_US
dc.typeArticleen_US
dc.identifier.citationFriedman LS. Dose--response relationship between in-hospital mortality and alcohol following acute injury. Alcohol. 2012 Dec;46(8):769-75. doi: 10.1016/j.alcohol.2012.08.006.


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