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dc.contributor.authorAlemzadeh, Ramin
dc.contributor.authorKichler, Jessica
dc.date.accessioned2013-12-06T17:04:59Z
dc.date.available2013-12-06T17:04:59Z
dc.date.issued2012-12
dc.identifier.bibliographicCitationAlemzadeh R, Kichler J. Parathyroid Hormone Is Associated with Biomarkers of Insulin Resistance and Inflammation, Independent of Vitamin D Status, in Obese Adolescents. Metabolic Syndrome and Related Disorders. Dec 2012;10(6):422-429. DOI: 10.1089/met.2012.0056en_US
dc.identifier.issn1540-4196
dc.identifier.urihttp://hdl.handle.net/10027/10853
dc.descriptionThis is a copy of an article published in the Metabolic Syndrome and Related Disorders © 2012 Copyright Mary Ann Liebert, Inc.; Metabolic Syndrome and Related Disorders is available online at: http://www.liebertonline.com.en_US
dc.description.abstractBackground: 25-Hydroxyvitamin D [25(OH)D] and parathyroid hormone (PTH) have been shown to correlate with several markers of metabolic syndrome in adult populations. We evaluated the relationship between circulating intact parathyroid hormone (iPTH) and 25(OH)D and indices of metabolic syndrome in obese adolescents. Methods: Body mass index (BMI), body composition, 25(OH) D, iPTH, fasting lipids, glucose, high-sensitivity C-reactive protein (hsCRP), glycosylated hemoglobin (HbA1c), insulin, and the homeostatic model assessment for insulin resistance (HOMA-IR) were evaluated in 133 obese adolescents. Results: Vitamin D deficiency [25(OH) D < 50 nmol/L] was present in 45.1% of all patients, with higher prevalence in African-American (AA) and Hispanic (H) than Caucasian (C) subgroups (63.9% and 56.4% vs. 25.9%; P < 0.001). iPTH and 25(OH) D were inversely correlated (r=-0.75; P < 0.0001), with AA displaying a higher iPTH: 25(OH) D ratio than H and C subgroups (P < 0.05). Whereas fat mass (FM) was negatively correlated with 25(OH) D (r= -0.30; p < 0.001), it was positively correlated with iPTH levels (r = 0.38; P < 0.0001). Metabolic syndrome was identified in 57.9% of the cohort with higher iPTH, iPTH: 25(OH) D ratio, but lower 25(OH) D than participants without metabolic syndrome (P < 0.02). Whereas iPTH showed main effects for hsCRP (beta = 0.24, t = 2.61, P < 0.05) and triglycerides: high-density lipoprotein cholesterol (TG: HDL-C) (beta = 0.21, t = 2.13, p < 0.05), independent of serum 25(OH)D, it did not reveal a main effect for HOMA-IR. Conclusions: Metabolic syndrome is associated with a higher iPTH: 25(OH)D ratio than those without metabolic syndrome, implying greater risk of cardiovascular morbidities among AA subjects than other ethnic groups. Furthermore, the serum iPTH level is a predictor of chronic inflammation and dyslipidemia, independent of 25(OH)D.en_US
dc.description.sponsorshipThis study was funded by the Diabetes Research Fund, Department of Pediatrics, Medical College of Wisconsin, Milwaukee, WIen_US
dc.language.isoen_USen_US
dc.publisherMary Ann Lieberten_US
dc.titleParathyroid Hormone Is Associated with Biomarkers of Insulin Resistance and Inflammation, Independent of Vitamin D Status, in Obese Adolescentsen_US
dc.typeArticleen_US
dc.identifier.citationAlemzadeh R, Kichler J. Parathyroid Hormone Is Associated with Biomarkers of Insulin Resistance and Inflammation, Independent of Vitamin D Status, in Obese Adolescents. Metabolic Syndrome and Related Disorders. Dec 2012;10(6):422-429. DOI: 10.1089/met.2012.0056


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