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dc.contributor.authorKroeger, Cynthia M
dc.contributor.authorKlempel, Monica C
dc.contributor.authorBhutani, Surabhi
dc.contributor.authorTrepanowski, John F
dc.contributor.authorTangney, Christine C
dc.contributor.authorVarady, Krista A
dc.date.accessioned2013-12-06T23:35:11Z
dc.date.available2013-12-06T23:35:11Z
dc.date.issued2012-10
dc.identifier.bibliographicCitationKroeger CM, Klempel MC, Bhutani S, Trepanowski JF, Tangney CC, Varady KA. Improvement in coronary heart disease risk factors during an intermittent fasting/calorie restriction regimen: Relationship to adipokine modulations. Nutrition & Metabolism. Oct 2012;9. DOI: 10.1186/1743-7075-9-98en_US
dc.identifier.issn1743-7075
dc.identifier.urihttp://hdl.handle.net/10027/10868
dc.description© 2012 Kroeger et al.; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The original version is available through BioMed Central at DOI: 10.1186/1743-7075-9-98.en_US
dc.description.abstractBackground: The ability of an intermittent fasting (IF)-calorie restriction (CR) regimen (with or without liquid meals) to modulate adipokines in a way that is protective against coronary heart disease (CHD) has yet to be tested. Objective: Accordingly, we examined the effects of an IFCR diet on adipokine profile, body composition, and markers of CHD risk in obese women. Methods: Subjects (n = 54) were randomized to either the IFCR-liquid (IFCR-L) or IFCR-food based (IFCR-F) diet for 10 weeks. Results: Greater decreases in body weight and waist circumference were noted in the IFCR-L group (4 +/- 1 kg; 6 +/- 1 cm) versus the IFCR-F group (3 +/- 1 kg; 4 +/- 1 cm). Similar reductions (P < 0.0001) in fat mass were demonstrated in the IFCR-L (3 +/- 1 kg) and IFCR-F group (2 +/- 1 kg). Reductions in total and LDL cholesterol levels were greater (P = 0.04) in the IFCR-L (19 +/- 10%; 20 +/- 9%, respectively) versus the IFCR-F group (8 +/- 3%; 7 +/- 4%, respectively). LDL peak particle size increased (P < 0.01) in the IFCR-L group only. The proportion of small LDL particles decreased (P < 0.01) in both groups. Adipokines, such as leptin, interleukin-6 (IL-6), tumor necrosis factor-alpha (TNF-alpha), and insulin-like growth factor-1 (IGF-1) decreased (P < 0.05), in the IFCR-L group only. Conclusion: These findings suggest that IFCR with a liquid diet favorably modulates visceral fat and adipokines in a way that may confer protection against CHD.en_US
dc.language.isoen_USen_US
dc.publisherBioMed Centralen_US
dc.subjectIntermittent fastingen_US
dc.subjectCalorie restrictionen_US
dc.subjectLiquid dieten_US
dc.subjectBody weighten_US
dc.subjectVisceral faten_US
dc.titleImprovement in coronary heart disease risk factors during an intermittent fasting/calorie restriction regimen: Relationship to adipokine modulationsen_US
dc.typeArticleen_US


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