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dc.contributor.authorBivalacqua, Trinity J.
dc.contributor.authorMusicki, Biljana
dc.contributor.authorHsu, Lewis L.
dc.contributor.authorBerkowitz, Dan E.
dc.contributor.authorChampion, Hunter C.
dc.contributor.authorBurnett, Arthur L.
dc.date.accessioned2014-02-19T03:24:02Z
dc.date.available2014-02-19T03:24:02Z
dc.date.issued2013-07
dc.identifier.bibliographicCitationBivalacqua TJ, Musicki B, Hsu LL, Berkowitz DE, Champion HC, et al. (2013) Sildenafil Citrate-Restored eNOS and PDE5 Regulation in Sickle Cell Mouse Penis Prevents Priapism Via Control of Oxidative/Nitrosative Stress. PLoS ONE 8(7): e68028. doi:10.1371/journal.pone.0068028en_US
dc.identifier.issn1932-6203
dc.identifier.urihttp://hdl.handle.net/10027/11160
dc.description© 2013 Bivalacqua et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. © 2013 by Public Library of Science, PLoS ONE.en_US
dc.description.abstractSildenafil citrate revolutionized the practice of sexual medicine upon its federal regulatory agency approval approximately 15 years ago as the prototypical phosphodiesterase type 5 inhibitor indicated for the treatment of male erectile dysfunction. We now provide scientific support for its alternative use in the management of priapism, a clinical disorder of prolonged and uncontrolled penile erection. Sildenafil administered continuously to sickle cell mice, which show a priapism phenotype, reverses oxidative/nitrosative stress effects in the penis, mainly via reversion of uncoupled endothelial nitric oxide synthase to the functional coupled state of the enzyme, which in turn corrects aberrant signaling and function of the nitric oxide/cyclic GMP/protein kinase G/phosphodiesterase type 5 cascade. Priapism tendencies in these mice are reverted partially toward normal neurostimulated erection frequencies and durations after sildenafil treatment in association with normalized cyclic GMP concentration, protein kinase G activity and phosphodiesterase type 5 activity in the penis. Thus, sildenafil exerts pleiotropic effects in the penis that extend to diverse erection disorders.en_US
dc.description.sponsorshipThis work was supported by US Public Service Grants HL090515 and RO1DK067223 (to ALB).en_US
dc.language.isoen_USen_US
dc.publisherPLoS Oneen_US
dc.titleSildenafil Citrate-Restored eNOS and PDE5 Regulation in Sickle Cell Mouse Penis Prevents Priapism Via Control of Oxidative/Nitrosative Stressen_US
dc.typeArticleen_US


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