Now showing items 1-10 of 18
Neural mechanisms of atrial arrhythmias
(Nature Publishing Group, 2011-09)
The past 5 years have seen great advances in the knowledge of neural mechanisms of atrial arrhythmogenesis. Direct autonomic nerve recordings demonstrate that simultaneous sympathovagal discharges and intrinsic cardiac ...
Integrative Structural Biomechanical Concepts of Ankylosing Spondylitis
(Hindawi Publishing Corporation, 2011-10)
Ankylosing spondylitis (AS) is not fully explained by inflammatory processes. Clinical, epidemiological, genetic, and course of disease features indicate additional host-related risk processes and predispositions. Collectively, ...
Endogenous Adipocyte ApoE is Co-localized with Caveolin at the Adipocyte Plasma Membrane
(American Society for Biochemistry and Molecular Biology, 2011-03)
Apolipoprotein E is well-established as a secreted protein that plays an important role in systemic lipoprotein metabolism and vascular wall homeostasis. Recently, endogenous expression of apoE in adipocytes has been shown ...
Pharmacodynamics of PEG-IFN alpha-2a and HCV response as a function of IL28B polymorphism in HIV/HCV co-infected patients
(Lippincott, Williams & Wilkins, 2011-02)
We examined the association between IL28B single‐nucleotide‐polymorphism rs12979860, hepatitis C virus (HCV) kinetic and pegylated‐interferon‐alpha‐2a pharmacodynamic parameters in HIV/HCV‐co‐infected patients from South ...
Conjugated Double Bonds in Lipid Bilayers: A Molecular Dynamic Simulation Study
Conjugated linoleic acids (CLA) are found naturally in dairy products. Two isomers of CLA, that differ only in the location of cis and trans double bonds, are found to have distinct and different biological effects. The ...
Role of Reactive Oxygen Species and Redox in Regulating the Function of Transient Receptor Potential Channels
(Mary Ann Liebert, 2011-04-11)
Cellular redox status, regulated by production of reactive oxygen species (ROS), greatly contributes to the regulation of vascular smooth muscle cell contraction, migration, proliferation, and apoptosis by modulating the ...
Thiazole antibiotic thiostrepton synergize with bortezomib to induce apoptosis in cancer cells
(Public Library of Science, 2011-02-18)
Thiazole antibiotic, thiostrepton was recently identified as proteasome inhibitor. We investigated the therapeutic potential of the combination of thiostrepton and proteasome inhibitor bortezomib (Velcade) on various human ...
An empirical analysis of overlap publication in Chinese language and English research manuscripts
(Public Library of Science, 2011-07-12)
Background There are a number of sound justifications for publishing nearly identical information in Chinese and English medical journals, assuming several conditions are met. Although overlap publication is perceived as ...
What we’ve got here is a failure to communicate
(Springer Verlag, 2011-02)
Incorporation profiles of conjugated linoleic acid isomers in cell membranes and their positional distribution in phospholipids
Although the conjugated linoleic acids (CLA) have several isomer-specific biological effects including anti-carcinogenic and anti-adipogenic effects, their mechanisms of action remain unclear. To determine their potential ...