Now showing items 1-10 of 24
African Ancestry Is Associated with Asthma Risk in African Americans
(Public Library of Science, 2012-01)
Background: Asthma is a common complex condition with clear racial and ethnic differences in both prevalence and severity. Asthma consultation rates, mortality, and severe symptoms are greatly increased in African descent ...
Suppression of FOXM1 Sensitizes Human Cancer Cells to Cell Death Induced by DNA-Damage
(Public Library of Science, 2012-02-29)
Irradiation and DNA-damaging chemotherapeutic agents are commonly used in anticancer treatments. Following DNA damage FOXM1 protein levels are often elevated. In this study, we sought to investigate the potential role of ...
Nitric oxide–dependent Src activation and resultant caveolin-1 phosphorylation promote eNOS/caveolin-1 binding and eNOS inhibition
(American Society for Cell Biology, 2012)
Endothelial nitric oxide synthase (eNOS)–mediated NO production plays a critical role in the regulation of vascular function and pathophysiology. Caveolin-1 (Cav-1) binding to eNOS holds eNOS in an inactive conformation; ...
Is Treatment Heterogeneity an Achilles' Heel For Comparative Effectiveness Research?
(IOS Press, 2012-07)
Complex Disease Networks of Trait-‐Associated SNPs Unveiled by Information Theory
(BMJ Publishing Group, 2012-03)
Objective: Thousands of complex disease SNPs have been discovered in Genome Wide Association Studies (GWAS). However, these intragenic SNPs have not been collectively mined to unveil the genetic architecture between ...
In the child with gastroenteritis that is unable to tolerate oral fluids, are there effective alternatives to intravenous hydration?
Nasogastric hydration is an effective alternative to intravenous hydration when oral hydration fails.
Molecular Signature of Kappa-Carrageenan Mimics Chondroitin-4-Sulfate and Dermatan Sulfate and Enables Interaction with Arylsulfatase B
The common food additive kappa-carrageenan ( -CGN) is a sulfated polysaccharide that resembles chondroitin-4-sulfate (C4S) and dermatan sulfate (DS). All have a sulfate group on C4 of a glycoside (galactose for carrageenan ...
Ablation of Leptin Signaling to Somatotropes: Changes in Metabolic Factors that Cause Obesity
(Endocrine Society, 2012-10)
Mice with somatotrope-specific deletion of the Janus kinase binding site in leptin receptors are GH deficient as young adults and become obese by 6 months of age. This study focused on the metabolic status of young (3– ...
Allergic Mastocytic Gastroenteritis and Colitis: An Unexplained Etiology in Chronic Abdominal Pain and Gastrointestinal Dysmotility
(Hindawi Publishing Corporation, 2012)
Abdominal pain, bloating, early satiety, and changes in bowel habits are common presenting symptoms in individuals with functional GI disorders. Emerging data suggests that these symptoms may be associated with mast cell ...
CFTR Modulates Acute Lung Injury: Evidence from A Genetic Association Study
(Lippincott, Williams & Wilkins, 2012-11)