Now showing items 1-10 of 33
Predictors of high sensitivity cardiac troponin T in chronic kidney disease patients: a cross-sectional study in the chronic renal insufficiency cohort (CRIC)
(BioMed Central, 2013-10)
Background Cardiac troponin T is independently associated with cardiovascular events and mortality in patients with chronic kidney disease (CKD). Serum levels of high sensitivity cardiac troponin T (hs-TnT) reflect ...
Susceptibility to ATP depletion of primary proximal tubular cell cultures derived from mice lacking either the alpha 1 or the alpha 2 isoform of the catalytic domain of AMPK
(BioMed Central, 2013-11)
Background The purpose of this study was to determine whether AMPK influences the survival of primary cultures of mouse proximal tubular (MPT) cells subjected to metabolic stress. Previous studies, using an immortalized ...
Chronic kidney disease is associated with adverse outcomes among elderly patients taking clopidogrel after hospitalization for acute coronary syndrome
(BioMed Central, 2013-05)
Background: Chronic kidney disease (CKD) is associated with worse outcomes among patients with acute coronary syndrome (ACS). Less is known about the impact of CKD on longitudinal outcomes among clopidogrel treated patients ...
Analysis of Hepatitis C Virus Decline during Treatment with the Protease Inhibitor Danoprevir Using a Multiscale Model
(Public Library of Science, 2013-03)
The current paradigm for studying hepatitis C virus (HCV) dynamics in patients utilizes a standard viral dynamic model that keeps track of uninfected (target) cells, infected cells, and virus. The model does not account ...
APOL1 Risk Variants, Race, and Progression of Chronic Kidney Disease
(Massachusetts Medical Society, 2013-12)
Background Among patients in the United States with chronic kidney disease, black patients are at increased risk for end-stage renal disease, as compared with white patients. Methods In two studies, we examined the ...
“There’s no cure for this condition”: How physicians discuss advance care planning in heart failure.
(Elsevier Inc., 2013-05)
Objective: To evaluate the extent to which physicians engage in recommended elements of advance care planning (ACP) communication during outpatient clinic visits with heart failure (HF) patients. Methods: We conducted ...
Trends and predictors in methadone maintenance treatment dropout in Shanghai, China: 2005-2011
(Informa Healthcare, 2013-07)
Background: The methadone maintenance treatment (MMT) program has been implemented in Shanghai since 2005. This study aims to portray the trend of MMT dropout and identify predictive factors that may influence dropout ...
High-Intensity Focused Ultrasound in Aesthetic Plastic Surgery
(Open Science, 2013-08)
Regulation of Tcf7l1 DNA Binding and Protein Stability as Principal Mechanisms of Wnt/b-Catenin Signaling
Wnt/β-catenin signal transduction requires direct binding of β-catenin to Tcf/Lef proteins, an event that is classically associated with stimulating transcription by recruiting coactivators. This molecular cascade plays ...
Arylsulfatase B (N-Acetylgalactosamine-4-Sulfatase): Potential Role as a Biomarker in Prostate Cancer
(Nature Publishing Group, 2013-09)
BACKGROUND: The enzyme arylsulfatase B (ARSB; N-acetylgalactosamine-4-sulfatase) degrades chondroitin-4-sulfate (C4S) and is reduced in malignant colonic and mammary tissues but has not previously been evaluated in prostate ...