Now showing items 1-10 of 11
Characterization of Mouse Models of Early Pancreatic Lesions Induced by Alcohol and Chronic Pancreatitis.
(Lippincott, Williams & Wilkins, 2015-08)
OBJECTIVE: We describe the first mouse model of pancreatic intraepithelial neoplasia (PanIN) lesions induced by alcohol in the presence and absence of chronic pancreatitis. METHODS: Pdx1-Cre;LSL-K-ras mice were exposed ...
A primary care, electronic health record-based strategy to promote safe drug use: study protocol for a randomized controlled trial.
(BioMed Central, 2015)
BACKGROUND: The Northwestern University Center for Education and Research on Therapeutics (CERT), funded by the Agency for Healthcare Research and Quality, is one of seven such centers in the USA. The thematic focus of ...
Decline in Arylsulfatase B and Increase in Chondroitin 4-Sulfotransferase Combine to Increase Chondroitin 4-Sulfate in Traumatic Brain Injury
(Wiley Periodicals Inc., 2015)
In an established rat model of penetrating ballistic-like brain injury (PBBI), arylsulfatase B (ARSB; N-acetylgalactosamine 4-sulfatase) activity was significantly reduced at the ipsilateral site of injury, but unaffected ...
Genetic polymorphism of APOB is associated with diabetes mellitus in sickle cell disease
(Springer Verlag, 2015-08)
Environmental variations have strong influences in the etiology of type 2 diabetes mellitus. In this study, we investigated the genetic basis of diabetes in patients with sickle cell disease (SCD), a Mendelian disorder ...
Preventing the NET negative in primary graft dysfunction.
(American Thoracic Society, 2015-02-15)
Administration of defined microbiota is protective in a murine Salmonella infection model.
(Nature Publishing Group, 2015-11-04)
Salmonella typhimurium is a major cause of diarrhea and causes significant morbidity and mortality worldwide, and perturbations of the gut microbiota are known to increase susceptibility to enteric infections. The purpose ...
NOS1-derived nitric oxide promotes NF-κB transcriptional activity through inhibition of suppressor of cytokine signaling-1.
(Rockefeller University Press, 2015-09-21)
The NF-κB pathway is central to the regulation of inflammation. Here, we demonstrate that the low-output nitric oxide (NO) synthase 1 (NOS1 or nNOS) plays a critical role in the inflammatory response by promoting the ...
Molecular Signatures of Immune Activation and Epithelial Barrier Remodeling Are Enhanced during the Luteal Phase of the Menstrual Cycle: Implications for HIV Susceptibility.
(American Society for Microbiology, 2015-09)
The variable infectivity and transmissibility of HIV/SHIV has been recently associated with the menstrual cycle, with particular susceptibility observed during the luteal phase in nonhuman primate models and ex vivo human ...
Approaches to achieving equality in respiratory health
(Elsevier Inc., 2015-03)
MnSOD upregulation sustains the Warburg effect via mitochondrial ROS and AMPK-dependent signalling in cancer.
(Nature Publishing Group, 2015-02-05)
Manganese superoxide dismutase (MnSOD/SOD2) is a mitochondria-resident enzyme that governs the types of reactive oxygen species egressing from the organelle to affect cellular signalling. Here we demonstrate that MnSOD ...