Publications - Microbiology and Immunology
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Evolutionary Constraints Shaping Streptococcus pyogenes-Host Interactions
(Elsevier, 2017-06)Research on the Gram-positive human-restricted pathogen Streptococcus pyogenes (Group A Streptococcus, GAS) has long focused on invasive illness, the most severe manifestations of GAS infection. Recent advances in descriptions ... -
Presence of Salmonella AvrA in colorectal tumor and its precursor lesions in mouse intestine and human specimens
(Oncotarget, 2017-07-06)Evidence directly supporting an association between Salmonella infection and colorectal cancer in human subjects is sparse. It has been well recognized that Salmonella infection increases the risk of gallbladder cancer. ... -
Mitochondrial protein 18 (MTP18) plays a pro-apoptotic role in chemotherapy-induced gastric cancer cell apoptosis
(Impact Journals, 2017-04-28)One of the severe limitations of chemotherapy is the development of drug resistance. However, the mechanisms underlying chemotherapy resistance remain to be elucidated. Mitochondrial mediated apoptosis is a form of cell ... -
Propofol increases host susceptibility to microbial infection by reducing subpopulations of mature immune effector cells at sites of infection
(Public Library of Science, 2015-09-18)Anesthetics are known to modulate host immune responses, but separating the variables of surgery from anesthesia when analyzing hospital acquired infections is often difficult. Here, the bacterial pathogen Listeria ... -
Elevated serum IL-35 and increased expression of IL-35-p35 or -EBI3 in CD4(+)CD25(+) T cells in patients with active tuberculosis.
(e-Century Publishing, 2016-02-15)Despite the recent appreciation of interleukin 35 (IL-35) function in inflammatory diseases, little is known for IL-35 response in patients with active tuberculosis (ATB). In the current study, we demonstrated that ATB ... -
Perforin-2 Protects Host Cells and Mice by Restricting the Vacuole to Cytosol Transitioning of a Bacterial Pathogen.
(American Society for Microbiology, 2016-03-24)The host-encoded Perforin-2 (encoded by the macrophage-expressed gene 1,Mpeg1), which possesses a pore-forming MACPF domain, reduces the viability of bacterial pathogens that reside within membrane-bound compartments. Here, ... -
Single cell super-resolution imaging of E. coli OmpR during environmental stress.
(Royal Society of Chemistry, 2015-10-01)Two-component signaling systems are a major strategy employed by bacteria, and to some extent, yeast and plants, to respond to environmental stress. The EnvZ/OmpR system in E. coli responds to osmotic and acid stress and ... -
During Infection, Theiler's Virions Are Cleaved by Caspases and Disassembled into Pentamers.
(American Society for Microbiology, 2016-01-20)Infected macrophages in spinal cords of mice persistently infected with Theiler’s murine encephalomyelitis virus (TMEV) undergo apoptosis, resulting in restricted virus yields, as do infected macrophages in culture. ... -
Extremely Long-Range Chromatin Loops Link Topological Domains to Facilitate a Diverse Antibody Repertoire.
(Elsevier (Cell Press), 2016-02-02)Early B cell development is characterized by large-scale Igh locus contraction prior to V(D)J recombination to facilitate a highly diverse Ig repertoire. However, an understanding of the molecular architecture that mediates ... -
CD11C antigen presenting cells with high B7-H4 expression in active tuberculosis patients are associated with low stimulatory capacity to T cell proliferation.
(e-Century Publishing, 2016-03-30)B7-H4 is a co-inhibitory molecule that negatively regulates T lymphocytes, playing a role in immune suppression many disorders. However, the role of antigen presenting cells (APCs)-expressing B7-H4 in active pulmonary ... -
Hierarchy Low CD4+/CD8+ T-Cell Counts and IFN-γ Responses in HIV-1+ Individuals Correlate with Active TB and/or M.tb Co-Infection.
(Public Library of Science, 2016-03-09)OBJECTIVE: Detailed studies of correlation between HIV-M.tb co-infection and hierarchy declines of CD8+/CD4+ T-cell counts and IFN-γ responses have not been done. We conducted case-control studies to address this ... -
Assessing bacterial invasion of cardiac cells in culture and heart colonization in infected mice using Listeria monocytogenes.
(Journal of Visualized Experiments, 2015-05-27)Listeria monocytogenes is a Gram-positive facultative intracellular pathogen that is capable of causing serious invasive infections in immunocompromised patients, the elderly, and pregnant women. The most common manifestations ... -
Apoptotic cells activate AMP-activated protein kinase (AMPK) and inhibit epithelial cell growth without change in intracellular energy stores.
(American Society for Biochemistry and Molecular Biology, 2015-09-11)Apoptosis plays an indispensable role in the maintenance and development of tissues. We have shown that receptor-mediated recognition of apoptotic target cells by viable kidney proximal tubular epithelial cells (PTECs) ... -
Henrin A: A New Anti-HIV Ent-Kaurane Diterpene from Pteris henryi.
(MDPI, 2015-11-24)Henrin A (1), a new ent-kaurane diterpene, was isolated from the leaves of Pteris henryi. The chemical structure was elucidated by analysis of the spectroscopic data including one-dimensional (1D) and two-dimensional (2D) ... -
miR-23a binds to p53 and enhances its association with miR-128 promoter.
(Nature Publishing Group, 2015-11-10)Apoptosis plays an important role in cardiac pathology, but the molecular mechanism by which apoptosis regulated remains largely elusive. Here, we report that miR-23a promotes the apoptotic effect of p53 in cardiomyocytes. ... -
Quorum sensing in group A Streptococcus
(Frontiers, 2014)Quorum sensing (QS) is a widespread phenomenon in the microbial world that has important implications in the coordination of population-wide responses in several bacterial pathogens. In Group A Streptococcus (GAS), many ... -
Complex Relationship between Mismatch Repair Proteins and MBD4 during Immunoglobulin Class Switch Recombination
(Public Library of Science, 2013)Mismatch repair (MMR) safeguards against genomic instability and is required for efficient Ig class switch recombination (CSR). Methyl CpG binding domain protein 4 (MBD4) binds to MutL homologue 1 (MLH1) and controls the ... -
Roles of a Novel Crp/Fnr Family Transcription Factor Lmo0753 in Soil Survival, Biofilm Production and Surface Attachment to Fresh Produce of Listeria monocytogenes
(Public Library of Science, 2013)Listeria monocytogenes is a foodborne bacterial pathogen and the causative agent of an infectious disease, listeriosis. L. monocytogenes is ubiquitous in nature and has the ability to persist in food processing environments ... -
Flexible ordering of antibody class switch and V(D)J joining during B-cell ontogeny
(Cold Spring Harbor Laboratory Press, 2013-11)V(D)J joining is mediated by RAG recombinase during early B-lymphocyte development in the bone marrow (BM). Activation-induced deaminase initiates isotype switching in mature B cells of secondary lymphoid structures. ... -
Characterization of the yehUT Two-Component Regulatory System of Salmonella enterica Serovar Typhi and Typhimurium
(Public Library of Science, 2014-01-05)Proteins exhibiting hyper-variable sequences within a bacterial pathogen may be associated with host adaptation. Several lineages of the monophyletic pathogen Salmonella enterica serovar Typhi (S. Typhi) have accumulated ...
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