Browsing Publications - Microbiology and Immunology by Issue Date
Now showing items 1-20 of 76
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AID-dependent histone acetylation is detected in immunoglobulin S regions
(Rockefeller University Press, 2006-01-17)Class switch recombination (CSR) is regulated by the expression of activation-induced deaminase ( AID) and germline transcripts (GLTs). AID-dependent double-strand breaks (DSBs) are introduced into switch ( S) regions and ... -
Resistance to TRAIL-induced apoptosis: role of IG20 splice variants
(American Association for Cancer Research, 2008-01)Tumor necrosis factor receptor–related apoptosis-inducing ligand (TRAIL) can induce apoptosis primarily in cancer cells with little or no effect on normal cells; therefore, it has the potential for use in cancer therapy. ... -
Assigning significance in label-free quantitative proteomics to include single-peptide-hit proteins with low replicates
(Hindawi Publishing Corporation, 2010-01-01)Selecting differentially regulated proteins with an assignment of statistical significance remains difficult for proteins with a single-peptide hit or a small fold-change when sample replicates are limited. This study ... -
Advances in protein turnover analysis at the global level and biological insights
(Wiley-Blackwell, 2010-09)The concept of a dynamic state of body constituents, a precursor of the modern term of proteome dynamics, was conceived over a century ago. But, not until recently can we examine the dynamics of individual ‘constituents’ ... -
Constitutive Activation of PrfA Tilts the Balance of Listeria monocytogenes Fitness Towards Life within the Host versus Environmental Survival
(Public Library of Science, 2010-12-07)PrfA is a key regulator of Listeria monocytogenes pathogenesis and induces the expression of multiple virulence factors within the infected host. PrfA is post-translationally regulated such that the protein becomes activated ... -
The anti-apoptotic Mcl-1 protein controls the type of cell death in Theiler’s virus-infected BHK-21 cells
(American Society for Microbiology, 2011)Theiler’s murine encephalomyelitis virus (TMEV) is a highly cytolytic RNA virus that produces a persistent central nervous system infection and immune-mediated demyelination in susceptible strains of mice. TMEV-infected ... -
Identification of critical residues of influenza neuraminidase in viral particle release
(BioMed Central, 2011-01-13)BACKGROUND: Influenza neuraminidase (NA) is essential for virus release from its host cells and it is one of the targets for structure-based antiviral drug design. RESULTS: In this report, we established a pseudoviral ... -
Thiazole antibiotic thiostrepton synergize with bortezomib to induce apoptosis in cancer cells
(Public Library of Science, 2011-02-18)Thiazole antibiotic, thiostrepton was recently identified as proteasome inhibitor. We investigated the therapeutic potential of the combination of thiostrepton and proteasome inhibitor bortezomib (Velcade) on various human ... -
An Herpesvirus Virulence Factor Inhibits Dendritic Cell Activation Through Protein Phosphatase 1 and IκB Kinase
(American Society for Microbiology, 2011-04)Dendritic cells are sentinels in innate and adaptive immunity. Upon virus infection, a complex program is in operation, which activates I kappa B kinase (IKK), a key regulator of inflammatory cytokines and costimulatory ... -
Regulation and Consequence of Serine Catabolism in Streptococcus pyogenes
(American Society for Microbiology, 2011-04)The Gram-positive bacterium Streptococcus pyogenes (Group A Streptococcus, GAS), is found strictly in humans and is capable of causing a wide variety of infections. Here we demonstrate that serine catabolism in GAS is ... -
Efficient Induction of CD25(-) iTreg by Co-Immunization Requires Strongly Antigenic Epitopes for T Cells
(BioMed Central, 2011-05-05)Background: We previously showed that co-immunization with a protein antigen and a DNA vaccine coding for the same antigen induces CD40(low) IL-10(high) tolerogenic DCs, which in turn stimulates the expansion of antigenspecific ... -
Probing the HIV GP120 Envelope Glycoprotein Conformation by NMR
(American Society for Biochemistry and Molecular Biology, 2011-07)The HIV envelope glycoprotein gp120 plays a critical role in virus entry and thus its structure is of extreme interest for the development of novel therapeutics and vaccines. To date, high resolution structural information ... -
Adaptation of Saffold Virus-2 for High-Titer Growth in Mammalian Cells
(American Society for Microbiology, 2011-07)Saffold viruses (SAFV) are a recently discovered group of human Cardioviruses closely related to Theiler's murine encephalomyelitis viruses (TMEV). Unlike TMEV and encephalomyocarditis virus, each of which is monotypic, ... -
IL-1β promotes TGF-β1 and IL-2 dependent Foxp3 expression in regulatory T cells
(Public Library of Science, 2011-07-11)Earlier, we have shown that GM-CSF-exposed CD8α- DCs that express low levels of pro-inflammatory cytokines IL-12 and IL-1β can induce Foxp3+ Tregs leading to suppression of autoimmunity. Here, we examined the differential ... -
IL-1β Promotes TGF-β1 and IL-2 Dependent Foxp3 Expression in Regulatory T Cells
(Public Library of Science, 2011-07-11)Earlier, we have shown that GM-CSF-exposed CD8a2 DCs that express low levels of pro-inflammatory cytokines IL-12 and IL-1b can induce Foxp3+ Tregs leading to suppression of autoimmunity. Here, we examined the differential ... -
Two Group A Streptococcal Peptide Pheromones Act through Opposing Rgg Regulators to Control Biofilm Development
(Public Library of Science, 2011-08-04)Streptococcus pyogenes (Group A Streptococcus, GAS) is an important human commensal that occasionally causes localized infections and less frequently causes severe invasive disease with high mortality rates. How GAS regulates ... -
Role of Cytokines in the Pathogenesis and Suppression of Thyroid Autoimmunity
(Mary Ann Liebert, 2011-08-08)Autoimmune thyroid diseases (AITD) are one of the most common organ-specific autoimmune disorders, of which Hashimoto's thyroiditis (HT) and Graves' disease (GD) are 2 of the most common clinical expressions. HT is ... -
Probing the Role of Protein Surface Charge in the Activation of PrfA, the Central Regulator of Listeria monocytogenes Pathogenesis
(Public Library of Science, 2011-08-12)Listeria monocytogenes is a food-borne intracellular bacterial pathogen capable of causing serious human disease. L. monocytogenes survival within mammalian cells depends upon the synthesis of a number of secreted virulence ... -
An Important Role for Syndecan-1 in Herpes Simplex Virus Type-1 Induced Cell-to-Cell Fusion and Virus Spread
(Public Library of Science, 2011-09)Herpes simplex virus type-1 (HSV-1) is a common human pathogen that relies heavily on cell-to-cell spread for establishing a lifelong latent infection. Molecular aspects of HSV-1 entry into host cells have been well ... -
The Fecal Viral Flora of Wild Rodents
(Public Library of Science, 2011-09)The frequent interactions of rodents with humans make them a common source of zoonotic infections. To obtain an initial unbiased measure of the viral diversity in the enteric tract of wild rodents we sequenced partially ...