Browsing Publications - Pharmacology by Title
Now showing items 1-20 of 75
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Activity of Ca -activated Cl channels contributes to regulating receptor- and store-operated Ca entry in human pulmonary artery smooth muscle cells
(Medknow Publications for the Pulmonary Vascular Research Institute (PVRI), 2011-04)Intracellular Ca(2+) plays a fundamental role in regulating cell functions in pulmonary arterial smooth muscle cells (PASMCs). A rise in cytosolic Ca(2+) concentration ([Ca(2+)](cyt)) triggers pulmonary vasoconstriction ... -
Allergies, antibiotics use, and multiple sclerosis
(TAYLOR & FRANCIS LTD, 2017)Background: The associations between allergies, antibiotics use, and multiple sclerosis (MS) remain controversial and their mediating or moderating effects have not yet been examined. We aimed to assess the direct and ... -
Angiotensin I-converting enzyme Gln1069Arg mutation impairs trafficking to the cell surface resulting in selective denaturation of the C-domain
(Public Library of Science, 2010-05-03)Background: Angiotensin-converting enzyme (ACE; Kininase II; CD143) hydrolyzes small peptides such as angiotensin I, bradykinin, substance P, LH-RH and several others and thus plays a key role in blood pressure regulation ... -
An Angiotensin I-Converting Enzyme Mutation (Y465D) Causes a Dramatic Increase in Blood ACE via Accelerated ACE Shedding
(Public Library of Science, 2011-10)Background: Angiotensin I-converting enzyme (ACE) metabolizes a range of peptidic substrates and plays a key role in blood pressure regulation and vascular remodeling. Thus, elevated ACE levels may be associated with an ... -
Are men at risk? The role of testosterone in cardiovascular morbidity
(Medknow Publications, 2012-07)Right ventricular (RV) function is affected by and contributes to a number of disease processes, including pulmonary hypertension (PH), congenital heart disease, left ventricular (LV) dysfunction, and valvular heart disease. ... -
Broad Expression Analysis of Human ANTXR1/TEM8 Transcripts Reveals Differential Expression and Novel Splizce Variants
(Public Library of Science, 2012-08)Tumor endothelial marker 8 (TEM8; ANTXR1) is one of two anthrax toxin receptors; the other is capillary morphogenesis gene 2 protein (CMG2; ANTXR2). TEM8 shows enhanced expression in certain tumor endothelia, and is thought ... -
The C-terminal unique region of desmoglein 2 inhibits its internalization via tail–tail interactions
(Rockefeller University Press, 2012-11-05)Desmosomal cadherins, desmogleins (Dsgs) and desmocollins, make up the adhesive core of intercellular junctions called desmosomes. A critical determinant of epithelial adhesive strength is the level and organization of ... -
Carboxypeptidase M augments kinin B1 receptor signaling by conformational crosstalk and enhances endothelial nitric oxide output
(Walter de Gruyter, 2013-03)The G protein-coupled receptors (GPCRs) are the largest class of membrane proteins that play key roles in transducing extracellular signals to intracellular proteins to generate cellular responses. The kinin GPCRs, named ... -
Caveolin-1–eNOS Signaling Promotes p190RhoGAP-A Nitration and Endothelial Permeability
(Rockefeller University Press, 2011-05-30)Endothelial barrier function is regulated by adherens junctions (AJs) and caveolae-mediated transcellular pathways. The opening of AJs that is observed in caveolin-1-/- (Cav-1-/-) endothelium suggests that Cav-1 is necessary ... -
CD44(high) alveolar type II cells show stem cell properties during steady-state alveolar homeostasis
(American Physiological Society, 2017-07)The alveolar epithelium is composed of type I cells covering most of the gas-blood exchange surface and type II cells secreting surfactant that lowers surface tension of alveoli to prevent alveolar collapse. Here, we have ... -
Characterization of dual agonists for kinin B1 and B2 receptors and their biased activation of B2 receptors
(Elsevier, 2012-08)Kinin B1 and B2 receptors (kB1R and kB2R) play important roles in many physiological and pathological processes. In some cases, kB1R or kB2R activation can have overlapping or complementary beneficial effects, thus an ... -
Cholesterol regulation of Pip(2): why cell type is so important
(Frontiers Research Foundation, 2013-01)A commentary on how cholesterol regulates endothelial biomechanics. -
CIB1 is an endogenous inhibitor of agonist-induced integrin aIIbb3 [alpha II b beta 3]activation
(Rockefeller University Press, 2006-01-17)In response to agonist stimulation, the alpha IIb beta 3 integrin on platelets is converted to an active conformation that binds fibrinogen and mediates platelet aggregation. This process contributes to both normal hemostasis ... -
Critical Role of Endothelial Hydrogen Peroxide in Post- Ischemic Neovascularization
(Public Library of Science, 2013-03)BACKGROUND: Reactive oxygen species (ROS) play an important role in angiogenesis in endothelial cells (ECs) in vitro and neovascularization in vivo. However, little is known about the role of endogenous vascular hydrogen ... -
Critical Role of Endothelial Hydrogen Peroxide in Post- Ischemic Neovascularization
(Public Library of Science, 2013-03)BACKGROUND: Reactive oxygen species (ROS) play an important role in angiogenesis in endothelial cells (ECs) in vitro and neovascularization in vivo. However, little is known about the role of endogenous vascular hydrogen ... -
Cross-talk between Carboxypeptidase M and the Kinin B1 Receptor Mediates a New Mode of G Protein-coupled Receptor Signaling
(American Society for Biochemistry and Molecular Biology, 2011-05)G protein-coupled receptor (GPCR) signaling is affected by formation of GPCR homo-or heterodimers, but GPCR regulation by other cell surface proteins is not well understood. We reported that the kinin B1 receptor (B1R) ... -
Differences in the mutation of the p53 gene in exons 6 and 7 in cervical samples from HIV- and HPV-infected women
(BioMed Central, 2013)Background Human Papillomavirus (HPV) infection is a serious problem for human immunodeficiency virus (HIV)-infected women, increases their risk of cervical lesions and cancer. In cervical carcinogenesis, mutations in the ... -
Differential regulation of inducible and endothelial nitric oxide synthase by kinin B1 and B2 receptors
(Elsevier, 2010-04)Kinins are vasoactive peptides that play important roles in cardiovascular homeostasis, pain and inflammation. After release from their precursor kininogens, kinins or their C-terminal des-Arg metabolites activate two ... -
Downregulation of kinin B1 receptor function by B2 receptor heterodimeriza- tion and signaling
(Elsevier Inc., 2015-01)Signaling through the G protein-coupled kinin receptors B1 (kB1R) and B2 (kB2R) plays a critical role in inflammatory responses mediated by activation of the kallikrein–kinin system. The kB2R is constitutively expressed ... -
Emerging Roles for Intersectin (ITSN) in Regulating Signaling and Disease Pathways
(MDPI, 2013-04)Intersectins (ITSNs) represent a family of multi-domain adaptor proteins that regulate endocytosis and cell signaling. ITSN genes are highly conserved and present in all metazoan genomes examined thus far. Lower eukaryotes ...