Browsing Publications - Pharmacology by Subject "endocytosis"
Now showing items 1-5 of 5
-
Characterization of dual agonists for kinin B1 and B2 receptors and their biased activation of B2 receptors
(Elsevier, 2012-08)Kinin B1 and B2 receptors (kB1R and kB2R) play important roles in many physiological and pathological processes. In some cases, kB1R or kB2R activation can have overlapping or complementary beneficial effects, thus an ... -
Emerging Roles for Intersectin (ITSN) in Regulating Signaling and Disease Pathways
(MDPI, 2013-04)Intersectins (ITSNs) represent a family of multi-domain adaptor proteins that regulate endocytosis and cell signaling. ITSN genes are highly conserved and present in all metazoan genomes examined thus far. Lower eukaryotes ... -
Intersectin 1 contributes to phenotypes in vivo: implications for Down Syndrome
(Lippincott, Williams & Wilkins, 2011-10)Intersectin 1 (ITSN1) is a chromosome 21 (HSA21) gene product encoding a multidomain scaffold protein that functions in endocytosis, signal transduction and is implicated in Down Syndrome, Alzheimer’s Disease, and ... -
Intersectin 1 Enhances Cbl Ubiquitylation of Epidermal Growth Factor Receptor through Regulation of Sprouty2-Cbl Interaction
(American Society for Microbiology, 2012-02)Ubiquitylation of receptor tyrosine kinases plays a critical role in regulating the trafficking and lysosomal degradation of these important signaling molecules. We identified the multidomain scaffolding protein intersectin ... -
Phosphatidic Acid Produced by RalA-activated PLD2 Stimulates Caveolae-mediated Endocytosis and Trafficking in Endothelial Cells.
(American Society for Biochemistry and Molecular Biology, 2016-09-23)Caveolae are the primary route for internalization and transendothelial transport of macromolecules, such as insulin and albumin. Caveolae-mediated endocytosis is activated by Src-dependent caveolin-1 (Cav-1) phosphorylation ...