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  • Smooth muscle cell-specific FoxM1 controls hypoxia-induced pulmonary hypertension 

    Dai, Jingbo; Zhou, Qiyuan; Tang, Haiyang; Chen, Tianji; Li, Jing; Raychaudhuri, Pradip; Yuan, Jason X.-J.; Zhou, Guofei (Elsevier, 2018-08-06)
    RATIONALE: Forkhead box M1 (FoxM1) is a transcription factor that promotes cell proliferation by regulating a broad spectrum of genes that participate in cell cycle regulation, such as Cyclin B, CDC25B, and Aurora B Kinase. ...
  • Insights into substrate promiscuity of human seryl-tRNA synthetase. 

    Holman, Kaitlyn, M.; Puppala, Anupama, K.; Lee, Jonathan, W.; Lee, Hyun; Simonovic, Miljan (Cold Spring Harbor Laboratory Press, 2017-08-14)
    Seryl-tRNA synthetase (SerRS) attaches L-serine to the cognate serine tRNA (tRNASer) and the noncognate selenocysteine tRNA (tRNASec). The latter activity initiates the anabolic cycle of selenocysteine (Sec), proper decoding ...
  • The matricellular protein CCN1 in tissue injury repair 

    Kim, Ki-Hyun; Won, Jong, Hoon; Cheng, Naiyuan; Lau, Lester, F. (Springer Verlag, 2018-01-22)
    The expression of Ccn1 (Cyr61) is essential for cardiovascular development during embryogenesis, whereas in adulthood it is associated with inflammation, wound healing, injury repair, and related pathologies including ...
  • Identification of a Unique Inhibitor-Binding Site on Choline Kinase α 

    Kall, Stefanie, L.; Delikatny, Edward, J.; Lavie, Arnon (American Chemical Society, 2018-02-01)
    Choline kinase α (ChoKα) is an enzyme that is upregulated in many types of cancer and has been shown to be tumorigenic. As such, it makes a promising target for inhibiting tumor growth. Though there have been several ...
  • Molecular Regulation of Protein Tyrosine Kinase 6 in Prostate Cancer 

    Wozniak, Darren J (2017-07-11)
    Protein tyrosine kinase 6 (PTK6) is an intracellular tyrosine kinase that is oncogenic when activated at the plasma membrane. Activation of PTK6 at the plasma membrane was previously observed in Pten-deficient mouse ...
  • The crystal structure of yeast mitochondrial ThrRS in complex with the canonical threonine tRNA 

    Holman, K. M.; Wu, J.; Ling, J. Q.; Simonovi, M. (Oxford University Press, 2015)
    In mitochondria of Saccharomyces cerevisiae, a single aminoacyl- TRNA synthetase (aaRS), MST1, aminoacylates two isoacceptor tRNAs, tRNA1 Thr and tRNA2 Thr, that harbor anticodon loops of different size and sequence. As a ...
  • The oesophageal string test: a novel, minimally invasive method measures mucosal inflammation in eosinophilic oesophagitis 

    Furuta, Glenn T.; Kagalwalla, Amir F.; Lee, James J.; Alumkal, Preeth; Maybruck, Brian T.; Fillon, Sophie; Masterson, Joanne C.; Ochkur, Sergei; Protheroe, Cheryl; Moore, Wendy; Pan, Zhaoxing; Amsden, Katie; Robinson, Zachary; Capocelli, Kelley; Mukkada, Vince; Atkins, Dan; Fleischer, David; Hosford, Lindsay; Kwatia, Mark A.; Schroeder, Shauna; Kelly, Caleb; Lovell, Mark; Melin-Aldana, Hector; Ackerman, Steven J. (BMJ Publishing Group, 2012-08-15)
    Objective: Eosinophil predominant inflammation characterises histological features of eosinophilic oesophagitis (EoE). Endoscopy with biopsy is currently the only method to assess oesophageal mucosal inflammation in EoE. ...
  • Stability and function of adult vasculature is sustained by Akt/Jagged1 signalling axis in endothelium. 

    Kerr, BA; West, XZ; Kim, YW; Zhao, Y; Tischenko, M; Cull, RM; Phares, TW; Peng, XD; Bernier-Latmani, J; Petrova, TV; Adams, RH; Hay, N; Naga Prasad, SV; Byzova, TV (Nature Publishing Group, 2016-03-14)
    The signalling pathways operational in quiescent, post-development vasculature remain enigmatic. Here we show that unlike neovascularization, endothelial Akt signalling in established vasculature is crucial not for endothelial ...
  • Biomarkers of the involvement of mast cells, basophils and eosinophils in asthma and allergic diseases. 

    Metcalfe, DD; Pawankar, R; Ackerman, Steven J.; Akin, C; Clayton, F; Falcone, FH; Gleich, GJ; Irani, AM; Johansson, MW; Klion, AD; Leiferman, KM; Levi-Schaffer, F; Nilsson, G; Okayama, Y; Prussin, C; Schroeder, JT; Schwartz, LB; Simon, HU; Walls, AF; Triggiani, M (BioMed Central, 2016-02-11)
    Biomarkers of disease activity have come into wide use in the study of mechanisms of human disease and in clinical medicine to both diagnose and predict disease course; as well as to monitor response to therapeutic ...
  • [18F]CFA as a clinically translatable probe for PET imaging of deoxycytidine kinase activity. 

    Kim, W; Le, TM; Wei, L; Poddar, S; Bazzy, J; Wang, X; Uong, NT; Abt, ER; Capri, JR; Austin, WR; Van Valkenburgh, JS; Steele, D; Gipson, RM; Slavik, R; Cabebe, AE; Taechariyakul, T; Yaghoubi, SS; Lee, JT; Sadeghi, S; Lavie, A; Faull, KF; Witte, ON; Donahue, TR; Phelps, ME; Herschman, HR; Herrmann, K; Czernin, J; Radu, CG (National Academy of Sciences, 2016-04-12)
    Deoxycytidine kinase (dCK), a rate-limiting enzyme in the cytosolic deoxyribonucleoside (dN) salvage pathway, is an important therapeutic and positron emission tomography (PET) imaging target in cancer. PET probes for dCK ...
  • Swi1Timeless Prevents Repeat Instability at Fission Yeast Telomeres. 

    Gadaleta, MC; Das, MM; Tanizawa, H; Chang, YT; Noma, K; Nakamura, TM; Noguchi, E (Public Library of Science, 2016-03-18)
    Genomic instability associated with DNA replication stress is linked to cancer and genetic pathologies in humans. If not properly regulated, replication stress, such as fork stalling and collapse, can be induced at natural ...
  • Precise regulation of the guidance receptor DMA-1 by KPC-1/Furin instructs dendritic branching decisions. 

    Dong, X; Chiu, H; Park, YJ; Zou, W; Zou, Y; Özkan, E; Chang, C; Shen, K (eLife Sciences Publications, 2016-03-14)
    Extracellular adhesion molecules and their neuronal receptors guide the growth and branching of axons and dendrites. Growth cones are attracted to intermediate targets, but they must switch their response upon arrival so ...
  • Systemic Akt1 Deletion after Tumor Onset in p53(-/-) Mice Increases Lifespan and Regresses Thymic Lymphoma Emulating p53 Restoration. 

    Yu, WN; Nogueira, V; Sobhakumari, A; Patra, KC; Bhaskar, PT; Hay, N (Elsevier (Cell Press), 2015-07-28)
    Akt is frequently activated in human cancers. However, it is unknown whether systemic inhibition of a single Akt isoform could regress cancer progression in cancers that are not driven by Akt activation. We systemically ...
  • Application of Virus-Like Particles (VLP) to NMR Characterization of Viral Membrane Protein Interactions 

    Caffrey, M.; Rong, L.J.; Bowlin, T.L.; Basu, A.; Kingsley, C.; Antanasijevic, Aleksandar M. (Springer Verlag, 2016-03)
    The membrane proteins of viruses play critical roles in the virus life cycle and are attractive targets for therapeutic intervention. Virus-like particles (VLP) present the possibility to study the biochemical and biophysical ...
  • Ccq1-Tpz1TPP1 interaction facilitates telomerase and SHREC association with telomeres in fission yeast. 

    Moser, BA; Raguimova, ON; Nakamura, TM (American Society for Cell Biology, 2015-11-01)
    Evolutionarily conserved shelterin complex is essential for telomere maintenance in the fission yeast Schizosaccharomyces pombe. Elimination of the fission yeast shelterin subunit Ccq1 causes progressive loss of telomeres ...
  • Increased mitochondrial function downstream from KDM5A histone demethylase rescues differentiation in pRB-deficient cells. 

    Váraljai, R; Islam, AB; Beshiri, ML; Rehman, J; Lopez-Bigas, N; Benevolenskaya, EV (Cold Spring Harbor Laboratory Press, 2015-09-01)
    The retinoblastoma tumor suppressor protein pRb restricts cell growth through inhibition of cell cycle progression. Increasing evidence suggests that pRb also promotes differentiation, but the mechanisms are poorly understood, ...
  • The crystal structure of yeast mitochondrial ThrRS in complex with the canonical threonine tRNA. 

    Holman, KM; Wu, J; Ling, J; Simonović, M (Oxford University Press, 2016-02-18)
    In mitochondria of Saccharomyces cerevisiae, a single aminoacyl-tRNA synthetase (aaRS), MST1, aminoacylates two isoacceptor tRNAs, tRNA1 (Thr) and tRNA2 (Thr), that harbor anticodon loops of different size and sequence. ...
  • Biomarkers of the involvement of mast cells, basophils and eosinophils in asthma and allergic diseases. 

    Metcalfe, DD; Pawankar, R; Ackerman, Steven J.; Akin, C; Clayton, F; Falcone, FH; Gleich, GJ; Irani, AM; Johansson, MW; Klion, AD (BioMed Central, 2016-02-11)
    Biomarkers of disease activity have come into wide use in the study of mechanisms of human disease and in clinical medicine to both diagnose and predict disease course; as well as to monitor response to therapeutic ...
  • Inhibition of Influenza H7 Hemagglutinin-Mediated Entry 

    Antanasijevic, Aleksandar M.; Cheng, Han; Wardrop, Duncan J; Rong, Lijun; Caffrey, Michael (Public Library of Science, 2013-11)
    The recent outbreak of H7N9 influenza in China is of high concern to public health. H7 hemagglutinin (HA) plays a critical role in influenza entry and thus HA presents an attractive target for antivirals. Previous studies ...
  • Fission Yeast Shelterin Regulates DNA Polymerases and Rad3(ATR) Kinase to Limit Telomere Extension 

    Chang, Ya-Ting; Moser, Bettina A; Nakamura, Toru M (Public Library of Science, 2013-11)
    Studies in fission yeast have previously identified evolutionarily conserved shelterin and Stn1-Ten1 complexes, and established Rad3ATR/Tel1ATM-dependent phosphorylation of the shelterin subunit Ccq1 at Thr93 as the critical ...

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