Now showing items 1-2 of 2
The matrix protein CCN1 (CYR61) induces apoptosis in fibroblasts
(Rockefeller University Press, 2005-11-07)
Integrin-mediated cell adhesion to extracellular matrix proteins is known to promote cell survival, whereas detachment from the matrix can cause rapid apoptotic death in some cell types. Contrary to this paradigm, we show ...
Smurf2 as a novel mitotic regulator: From the spindle assembly checkpoint to tumorigenesis
(BioMed Central, 2009-07-07)
The execution of the mitotic program with high fidelity is dependent upon precise spatiotemporal regulation of posttranslational protein modifications. For example, the timely polyubiquitination of critical mitotic regulators ...