Now showing items 1-10 of 57
A Vps21 endocytic module regulates autophagy.
(American Society for Cell Biology, 2014-10-15)
In autophagy, the double-membrane autophagosome delivers cellular components for their degradation in the lysosome. The conserved Ypt/Rab GTPases regulate all cellular trafficking pathways, including autophagy. These GTPases ...
Potential use of potassium efflux-deficient yeast for studying trafficking signals and potassium channel functions
The activity of potassium (K(+)) channels critically depends on their density on the cell surface membrane, which is regulated by dynamic protein-protein interactions that often involve distinct trafficking signals on the ...
TNFa-Induced Apoptosis Enabled by CCN1/CYR61: Pathways of Reactive Oxygen Species Generation and Cytochrome c Release
(Public Library of Science, 2012-02)
Although TNFa is a strong inducer of apoptosis, its cytotoxicity in most normal cells in vitro requires blockade of NFkB signaling or inhibition of de novo protein synthesis, typically by the addition of cycloheximide. ...
Intersectin 1 Enhances Cbl Ubiquitylation of Epidermal Growth Factor Receptor through Regulation of Sprouty2-Cbl Interaction
(American Society for Microbiology, 2012-02)
Ubiquitylation of receptor tyrosine kinases plays a critical role in regulating the trafficking and lysosomal degradation of these important signaling molecules. We identified the multidomain scaffolding protein intersectin ...
Suppression of FOXM1 Sensitizes Human Cancer Cells to Cell Death Induced by DNA-Damage
(Public Library of Science, 2012-02-29)
Irradiation and DNA-damaging chemotherapeutic agents are commonly used in anticancer treatments. Following DNA damage FOXM1 protein levels are often elevated. In this study, we sought to investigate the potential role of ...
Sequences at the interface of the fifth immunoglobulin domain and first fibronectin type III repeat of the neural cell adhesion molecule are critical for its polysialylation
(American Society for Biochemistry and Molecular Biology, 2011-02)
Novel Device to Sample the Esophageal Microbiome — The Esophageal String Test
(Public Library of Science, 2012-09)
A growing number of studies implicate the microbiome in the pathogenesis of intestinal inflammation. Previous work has shown that adults with esophagitis related to gastroesophageal reflux disease have altered esophageal ...
Regulation of Tcf7l1 DNA Binding and Protein Stability as Principal Mechanisms of Wnt/b-Catenin Signaling
Wnt/β-catenin signal transduction requires direct binding of β-catenin to Tcf/Lef proteins, an event that is classically associated with stimulating transcription by recruiting coactivators. This molecular cascade plays ...
Regulation of ER-phagy by a Ypt/Rab GTPase module
(American Society for Cell Biology, 2013-10)
Accumulation of misfolded proteins on intracellular membranes has been implicated in neurodegenerative diseases. One cellular pathway that clears such aggregates is endoplasmic reticulum autophagy (ER-phagy), a selective ...
Intersectin (ITSN) Family of Scaffolds Function as Molecular Hubs in Protein Interaction Networks
(Public Library of Science, 2012-04)
Members of the intersectin (ITSN) family of scaffold proteins consist of multiple modular domains, each with distinct ligand preferences. Although ITSNs were initially implicated in the regulation of endocytosis, subsequent ...