Now showing items 1-4 of 4
Modulation of Neurotransmission by GPCRs Is Dependent upon the Microarchitecture of the Primed Vesicle Complex
(Society for Neuroscience, 2014-01-02)
Gi/o-protein-coupled receptors (GPCRs) ubiquitously inhibit neurotransmission, principally via Gβγ, which acts via a number of possible effectors. GPCR effector specificity has traditionally been attributed to Gα, based ...
Synaptic NMDA Receptor-Dependent Ca2+ Entry Drives Membrane Potential and Ca2+ Oscillations in Spinal Ventral Horn Neurons
(PLoS One, 2013-04)
During vertebrate locomotion, spinal neurons act as oscillators when initiated by glutamate release from descending systems. Activation of NMDA receptors initiates Ca2+-mediated intrinsic membrane potential oscillations ...
Sensory Activation of Command Cells for Locomotion and Modulatory Mechanisms: Lessons from Lampreys.
(Frontiers Media, 2016-03-22)
Sensorimotor transformation is one of the most fundamental and ubiquitous functions of the central nervous system (CNS). Although the general organization of the locomotor neural circuitry is relatively well understood, ...
Acute dissociation of lamprey reticulospinal axons to enable recording from the release face membrane of individual functional presynaptic terminals.
(Journal of Visualized Experiments, 2014-10-01)
Synaptic transmission is an extremely rapid process. Action potential driven influx of Ca(2+) into the presynaptic terminal, through voltage-gated calcium channels (VGCCs) located in the release face membrane, is the trigger ...