Now showing items 1-5 of 5
Function of conserved transcription factors in the C. elegans somatic gonad and pharynx
Mammalian EGR-family genes and T-box family genes are broadly expressed and mutants result in a variety of defects and diseases (O'Donovan et al., 1999). To aid in our understanding of how these transcription factor ...
Leveraging Genomic and Microarray Data to Find Direct Targets of the C. elegans Transcription Factor TBX-2
Four independent methods were used to produce a data set enriched for direct targets of C. elegans TBX-2. A microarray experiment comparing wild-type and mutant tbx-2 embryos was analyzed, resulting in a set of ...
Function of the C. elegans T-box factor TBX-2 depends on SUMOylation
(Springer Verlag, 2013-04)
T-box transcription factors are critical developmental regulators in all multi-cellular organisms, and altered T-box factor activity is associated with a variety of human congenital diseases and cancers. Despite the ...
Caenorhabditis elegans TBX-2 Directly Regulates Its Own Expression in a Negative Autoregulatory Loop
(Genetics Society of America, 2015-06-01)
T-box genes often exhibit dynamic expression patterns, and their expression levels can be crucial for normal function. Despite the importance of these genes, there is little known about T-box gene regulation. We have focused ...
SUMOylation is Required for Function of the Caenorhabditis elegans T-box Transcription Factor, TBX-2
T-box proteins are important dose-dependent developmental regulators of multicellular organisms, but little information exists regarding regulation of T-box factors in vivo. We are studying C. elegans TBX-2 to elucidate ...