Show simple item record

dc.contributor.authorJudex, S.
dc.contributor.authorKoh, T.
dc.contributor.authorXie, L.
dc.date.accessioned2016-01-22T17:41:32Z
dc.date.available2016-01-22T17:41:32Z
dc.date.issued2014-01-13
dc.identifier.bibliographicCitationJudex, S., Koh, T. J. and Xie, L. Modulation of bone’s sensitivity to low-intensity vibrations by acceleration magnitude, vibration duration, and number of bouts. Osteoporosis International. 2015. DOI: 10.1007/s00198-014-3018-5.en_US
dc.identifier.issn0937-941X
dc.identifier.urihttp://hdl.handle.net/10027/20042
dc.descriptionPost print version of article may differ from published version. The final publication is available at springerlink.com; DOI: 10.1007/s00198-014-3018-5.en_US
dc.description.abstractVariables defining vibration-based biomechanical treatments were tested by their ability to affect the musculoskeleton in the growing mouse. Duration of a vibration bout, but not variations in vibration intensity or number of vibration bouts per day, was identified as modulator of trabecular bone formation rates. INTRODUCTION: Low-intensity vibrations (LIV) may enhance musculoskeletal properties, but little is known regarding the role that individual LIV variables play. We determined whether acceleration magnitude and/or the number and duration of daily loading bouts may modulate LIV efficacy. METHODS: LIV was applied to 8-week-old mice at either 0.3 g or 0.6 g for three weeks; the number of daily bouts was one, two, or four, and the duration of a single bout was 15, 30, or 60 min. A frequency of 45 Hz was used throughout. RESULTS: LIV induced tibial cortical surface strains in 4-month-old mice of approximately 10 με at 0.3 g and 30 με at 0.6 g. In trabecular bone of the proximal tibial metaphysis, all single daily bout signal combinations with the exception of a single 15 min daily bout at 0.3 g (i.e., single bouts of 30 and 60 min at 0.3 g and 15 and 30 min at 0.6 g) produced greater bone formation rates (BFR/BS) than in controls. Across all signal combinations, 30 and 60 min bouts were significantly more effective than 15 min bouts in raising BFR/BS above control levels. Increasing the number of daily bouts or partitioning a single daily bout into several shorter bouts did not potentiate efficacy and in some instances led to BFR/BS that was not significantly different from those in controls. Bone chemical and muscle properties were similar across all groups. CONCLUSIONS: These data may provide a basis towards optimization of LIV efficacy and indicate that in the growing mouse skeleton, increasing bout duration from 15 to 30 or 60 min positively influences BFR/BS.en_US
dc.description.sponsorshipFunding by the US Army Medical Research and Material Command (DAMD 17-03-1-0777), the Department of Defense (DoD W81XWH-14-1-0281), and the National Institutes of Health (NBIB EB01435101A) was greatly appreciated.en_US
dc.publisherSpringer Verlagen_US
dc.subjectLow intensity vibrationsen_US
dc.subjectbone formationen_US
dc.subjectbone resorptionen_US
dc.subjecttrabecular boneen_US
dc.subjectcortical boneen_US
dc.subjectmuscle massen_US
dc.subjectmechanical strainen_US
dc.titleModulation of Bone’s Sensitivity to Low-Intensity Vibrations by Acceleration Magnitude, Vibration Duration, and Number of Boutsen_US
dc.typeArticleen_US


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record