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dc.contributor.authorRhee, J.
dc.contributor.authorNejad, T.M.
dc.contributor.authorComets, O.
dc.contributor.authorFlannery, S.
dc.contributor.authorGulsoy, E.B.
dc.contributor.authorIannaccone, P.
dc.contributor.authorFoster, C.
dc.date.accessioned2016-01-29T18:43:47Z
dc.date.available2017-01-30T10:30:05Z
dc.date.issued2015-01
dc.identifier.bibliographicCitationRhee, J., Nejad, T. M., Comets, O., Flannery, S., Gulsoy, E. B., Iannaccone, P. and Foster, C. Promoting Convergence: The Phi Spiral in Abduction of Mouse Corneal Behaviors. Complexity. 2015. 20(3): 22-38. DOI: 10.1002/cplx.21562.en_US
dc.identifier.issn1076-2787
dc.identifier.urihttp://hdl.handle.net/10027/20086
dc.descriptionThis is the pre-peer reviewed version of the following article: Rhee, J., Nejad, T. M., Comets,O., Flannery, S., Gulsoy, E. B., Iannaccone, P. and Foster, C. Promoting Convergence: The Phi Spiral in Abduction of Mouse Corneal Behaviors. Complexity. 2015. 20(3): 22-38. DOI: 10.1002/cplx.21562., which has been published in final form at onlinelibrary.wiley.com/doi/10.1002/cplx.21562/epdf.en_US
dc.description.abstractWhy do mouse corneal epithelial cells display spiraling patterns? We want to provide an explanation for this curi-ous phenomenon by applying an ide alized pro blem so lving process. S pecifically, we applied co mplementary line-fitting methods to measure transgenic epithelial reporter expression arrangements displayed on three mature, liveenucleated globes to clarify the problem. Two prominent logarithmic curves were discovered, one of which displayedthe / ratio, an indicator of an optimal configuration in phyllotactic systems. We then utilized two different compu-ta tional appro aches to expose our current understanding ofthebehavior.Inoneprocedure,whichinvolvedaniso-tropic mechanics-based finite element method, we successfully produced logarithmic spiral curves of maximumshear strain based pathlines but computed dimensions displayed pitch angles of 35(/ spiral is 17), which wasaltered when we fitted the model with published measurements of coarse collagen orientations. We then usedmodel-based r easoning in context of Peircean abduction to select a wor king hypothesis. Our wor k serves as a conciseexample of applying a scientific habit of mind and illustrates nuances of ex ecuting a common method to doin gintegrative science.VC2014 Wiley P erio dicals, Inc. Complexity 20: 22– 38, 2015en_US
dc.description.sponsorshipThe research was supported by NIH 1R21EY020946-01 (JR, PMI, CF), NINDS NS054850 (subcontract, PMI)and the George M. Eisenberg Foundation for Charities(PMI).en_US
dc.publisherWiley Periodicals Inc.en_US
dc.subjectphi ratioen_US
dc.subjectmouse corneaen_US
dc.subjectPeircean abductionen_US
dc.subjectscientific methoden_US
dc.subjectCollagenen_US
dc.titlePromoting Convergence: The Phi Spiral in Abduction of Mouse Corneal Behaviorsen_US
dc.typeArticleen_US


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