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dc.contributor.authorCone JJ
dc.contributor.authorFortin SM
dc.contributor.authorMcHenry JA
dc.contributor.authorStuber GD
dc.contributor.authorMcCutcheon JE
dc.contributor.authorRoitman MF
dc.date.accessioned2016-08-01T19:22:10Z
dc.date.available2016-08-01T19:22:10Z
dc.date.issued2016-02-16
dc.identifier.bibliographicCitationCone, J. J., Fortin, S. M., McHenry, J. A., Stuber, G. D., McCutcheon, J. E. and Roitman, M. F. Physiological state gates acquisition and expression of mesolimbic reward prediction signals. Proceedings of the National Academy of Sciences of the United States of America. 2016. 113(7): 1943-1948. DOI: 10.1073/pnas.1519643113.en_US
dc.identifier.otherESSN: 1091-6490
dc.identifier.urihttp://hdl.handle.net/10027/21000
dc.descriptionThis is a copy of an article published in the Proceedings of the National Academy of Sciences. © 2016 National Academy of Sciences Publications.en_US
dc.description.abstractPhasic dopamine signaling participates in associative learning by reinforcing associations between outcomes (unconditioned stimulus; US) and their predictors (conditioned stimulus; CS). However, prior work has always engendered these associations with innately rewarding stimuli. Thus, whether dopamine neurons can acquire prediction signals in the absence of appetitive experience and update them when the value of the outcome changes remains unknown. Here, we used sodium depletion to reversibly manipulate the appetitive value of a hypertonic sodium solution while measuring phasic dopamine signaling in rat nucleus accumbens. Dopamine responses to the NaCl US following sodium depletion updated independent of prior experience. In contrast, prediction signals were only acquired through extensive experience with a US that had positive affective value. Once learned, dopamine prediction signals were flexibly expressed in a state-dependent manner. Our results reveal striking differences with respect to how physiological state shapes dopamine signals evoked by outcomes and their predictors.en_US
dc.description.sponsorshipThis work was supported by NIH Grants R01 DA025634 (to M.F.R.), K01 DA033380 (to J.E.M.), R01 DA038168 (to G.D.S.), and T32 MH093315 (to J.A.M.) and by the University of Illinois at Chicago Dean’s Scholar Fellowship (to J.J.C.).en_US
dc.language.isoen_USen_US
dc.publisherNational Academy of Sciencesen_US
dc.subjectdopamineen_US
dc.subjectlearningen_US
dc.subjectmotivationen_US
dc.subjectnucleus accumbensen_US
dc.subjectvoltammetryen_US
dc.titlePhysiological state gates acquisition and expression of mesolimbic reward prediction signals.en_US
dc.typeArticleen_US


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