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dc.contributor.authorZhao, Y.
dc.contributor.authorBao, L.
dc.contributor.authorChan, L. S.
dc.contributor.authorDiPietro, L. A.
dc.contributor.authorChen, L.
dc.date.accessioned2016-09-12T21:27:19Z
dc.date.available2016-09-12T21:27:19Z
dc.date.issued2016-01-11
dc.identifier.bibliographicCitationZhao, Y., Bao, L., Chan, L. S., DiPietro, L. A. and Chen, L. Aberrant wound healing in an epidermal interleukin-4 transgenic mouse model of atopic dermatitis. PLoS One. 2016. 11(1). DOI: 10.1371/journal.pone.0146451.en_US
dc.identifier.issn1932-6203
dc.identifier.urihttp://hdl.handle.net/10027/21144
dc.descriptionThis is a copy of an article published in the PLoS ONE. © 2016 Zhao et al.en_US
dc.description.abstractWound healing in a pre-existing Th2-dominated skin milieu was assessed by using an epidermal specific interleukin-4 (IL-4) transgenic (Tg) mouse model, which develops a pruritic inflammatory skin condition resembling human atopic dermatitis. Our results demonstrated that IL-4 Tg mice had delayed wound closure and re-epithelialization even though these mice exhibited higher degrees of epithelial cell proliferation. Wounds in IL-4 Tg mice also showed a marked enhancement in expression of inflammatory cytokines/chemokines, elevated infiltration of inflammatory cells including neutrophils, macrophages, CD3+ lymphocytes, and epidermal dendritic T lymphocytes. In addition, these mice exhibited a significantly higher level of angiogenesis as compared to wild type mice. Furthermore, wounds in IL-4 Tg mice presented with larger amounts of granulation tissue, but had less expression and deposition of collagen. Taken together, an inflamed skin condition induced by IL-4 has a pronounced negative influence on the healing process. Understanding more about the pathogenesis of wound healing in a Th2- dominated environment may help investigators explore new potential therapeutic strategies.en_US
dc.description.sponsorshipThis study was supported by NIH Grants R01GM50875 (LAD), College of Dentistry, University of Illinois at Chicago (LC, YZ, and LAD), Dr. Orville J. Stone Endowed Professorship (LSC), and the Albert H. and Mary Jane Slepyan Endowed Fellowship (LB).en_US
dc.language.isoen_USen_US
dc.publisherPublic Library of Scienceen_US
dc.subjectepidermalen_US
dc.subjectinterleukin-4en_US
dc.subjectatopic dermatitisen_US
dc.subjecttransgenic mouseen_US
dc.subjectwound healingen_US
dc.titleAberrant wound healing in an epidermal interleukin-4 transgenic mouse model of atopic dermatitisen_US
dc.typeArticleen_US


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