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dc.contributor.authorBulka C
dc.contributor.authorNastoupil LJ
dc.contributor.authorKoff JL
dc.contributor.authorBernal-Mizrachi L
dc.contributor.authorWard KC
dc.contributor.authorWilliams JN
dc.contributor.authorBayakly AR
dc.contributor.authorSwitchenko JM
dc.contributor.authorWaller LA
dc.contributor.authorFlowers CR
dc.date.accessioned2016-12-19T16:46:18Z
dc.date.available2017-09-20T09:30:13Z
dc.date.issued2016-10
dc.identifier.bibliographicCitationBulka, C., Nastoupil, L. J., Koff, J. L., Bernal-Mizrachi, L., Ward, K. C., Williams, J. N., Bayakly, A. R., Switchenko, J. M., Waller, L. A. and Flowers, C. R. Relations Between Residential Proximity to EPA-Designated Toxic Release Sites and Diffuse Large B-Cell Lymphoma Incidence. Southern Medical Journal. 2016. 109(10): 606-614. doi: 10.14423/SMJ.0000000000000545.en_US
dc.identifier.issn0038-4348
dc.identifier.urihttp://hdl.handle.net/10027/21431
dc.descriptionThis is a non-final version of an article published in final form in Bulka, C., Nastoupil, L. J., Koff, J. L., Bernal-Mizrachi, L., Ward, K. C., Williams, J. N., Bayakly, A. R., Switchenko, J. M., Waller, L. A. and Flowers, C. R. Relations between residential proximity to EPA-designated toxic release sites and diffuse large b-cell lymphoma incidence. Southern Medical Journal. 2016. 109(10): 606-614. DOI:10.14423/SMJ.0000000000000545.en_US
dc.description.abstractOBJECTIVES: Examining the spatial patterns of diffuse large B-cell lymphoma (DLBCL) incidence and residential proximity to toxic release locations may provide insight regarding environmental and sociodemographic risk factors. METHODS: We linked and geocoded cancer incidence data for the period 1999-2008 from the Georgia Comprehensive Cancer Registry with population data from the US Census and the Environmental Protection Agency's Toxics Release Inventory. We conducted cluster analyses and constructed Poisson regression models to assess DLBCL incidence as a function of mean distance to the toxic release sites. RESULTS: In total, 3851 incident DLBCL cases occurred among adults residing in Georgia between 1999 and 2008. Significant focal clustering was observed around 57% of ethylene oxide sites, 5% of benzene sites, 9% of tetrachloroethylene sites, 7% of styrene sites, 10% of formaldehyde sites, 5% of trichloroethylene sites, and 10% of all release sites. Mean distance to sites was significantly associated with DLBCL risk for all chemicals. CONCLUSIONS: Proximity to Toxics Release Inventory sites can be linked to increased DLBCL risk as assessed through focal clustering and Poisson regression, and confirmatory studies using geospatial mapping can aid in further specifying risk factors for DLBCL.en_US
dc.description.sponsorshipGrant Support: R21 CA158686/CA/NCI NIH HHS/United Statesen_US
dc.publisherLippincott, Williams & Wilkinsen_US
dc.subjectdiffuse large B-cell lymphomaen_US
dc.subjectepidemiologyen_US
dc.subjectlymphomaen_US
dc.subjectnon-Hodgkin lymphomaen_US
dc.titleRelations Between Residential Proximity to EPA-Designated Toxic Release Sites and Diffuse Large B-Cell Lymphoma Incidence.en_US
dc.typeArticleen_US


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