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dc.contributor.authorShoshany, O.
dc.contributor.authorAbhyankar, N.
dc.contributor.authorMufarreh, N.
dc.contributor.authorDaniel, G.
dc.contributor.authorNiederberger, C.
dc.date.accessioned2017-06-19T19:16:55Z
dc.date.available2017-06-19T19:16:55Z
dc.date.issued2017-03
dc.identifier.bibliographicCitationShoshany, O., Abhyankar, N., Mufarreh, N., Daniel, G. and Niederberger, C. Outcomes of anastrozole in oligozoospermic hypoandrogenic subfertile men. Fertility and Sterility. 2016. DOI: 10.1016/j.fertnstert.2016.11.021.en_US
dc.identifier.issn0015-0282
dc.identifier.urihttp://hdl.handle.net/10027/21656
dc.descriptionNOTICE: This is the author’s version of a work that was accepted for publication in Fertility and Sterility. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. A definitive version was subsequently published in Fertility and Sterility, Volume 107, Issue 3, March 2017, Pages 589–594 DOI: 10.1016/j.fertnstert.2016.11.021.en_US
dc.description.abstractObjective To determine whether the change in sperm parameters in subfertile hypoandrogenic men treated with anastrozole is correlated to the magnitude of increase in testosterone (T) to estrogen ratio in men responding to treatment. Design Retrospective study. Setting Male fertility clinic. Patient(s) The study group consisted of 86 subfertile hypoandrogenic men with low T/estradiol (E2) ratio (n = 78) or a prior aversive reaction to clomiphene citrate (n = 8). Intervention(s) All patients were treated with 1 mg anastrozole daily, administered orally. Main Outcome Measure(s) Hormone analysis and semen analysis before and after treatment were performed. Hormone analysis included measurements of total T, E2, sex-hormone binding globulin, albumin, FSH, and LH, and bioavailable T was calculated. Total motile sperm count was calculated from the semen analysis. Result(s) In all, 95.3% of patients had an increased serum T and decreased serum E2 after treatment with anastrozole. Sperm concentration and total motile counts improved in 18 of 21 subfertile hypoandrogenic oligozoospermic men treated with anastrozole. In these men the magnitude of total motile count increase was significantly correlated with the change in the T/E2 ratio. No improvement was seen in semen parameters of men with azoospermia, cryptozoospermia, or normozoospermia at presentation. Conclusion(s) Approximately 95% of men with hypoandrogenism responded with improved endocrine parameters, and a subset of oligozoospermic men (approximately 25% of all patients) displayed significantly improved sperm parameters. In that subset, increase in sperm parameters was correlated with the change in the T/E2 ratio, which argues for a physiologic effect of treatment.en_US
dc.publisherElsevieren_US
dc.subjectAnastrozoleen_US
dc.subjectaromatase inhibitorsen_US
dc.subjectmale infertilityen_US
dc.subjectoligozoospermiaen_US
dc.subjecttestosterone to estradiol ratioen_US
dc.titleOutcomes of anastrozole in oligozoospermic hypoandrogenic subfertile menen_US
dc.typeArticleen_US


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