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dc.contributor.advisorChe, Chun-Tao
dc.creatorGunn, Jordan J
dc.date.accessioned2018-11-27T16:29:01Z
dc.date.available2018-11-27T16:29:01Z
dc.date.created2018-08
dc.date.issued2018-07-10
dc.date.submittedAugust 2018
dc.identifier.urihttp://hdl.handle.net/10027/22981
dc.description.abstractThis thesis concerns antidiabetic studies on the plant species Alisma orientale which has a long history of being used traditionally for this purpose. The aim of this research is to analyze the antidiabetic activity previously reported, to determine active principles that help to explain this species’ biological activity as a whole, to provide justification for the traditional use of this plant, and to explore leads for the development of antidiabetic remedies, as well as the standardization of herbal complexes which utilize in part this species in the treatment or prevention of diabetes and its complications. Such information is potentially useful for a number of populations including traditional healers, researches, and practitioners. The project employed various chemical separation techniques including extraction, partitioning, open column chromatography, thin-layer chromatography, and high-performance chromatography, as well as numerous detection and characterization methods including spray reagents, UV-Vis, mass spectrometry, and nuclear magnetic resonance spectroscopy. Additionally, various biological tests were conducted including an in vivo streptozotocin animal study, and in vitro glucose-gut absorption, glucose-uptake induction, and α-glucosidase inhibition assays. In the end the project observed possible antidiabetic activity of Alisma orientale and its components in vivo and in vitro in the glucose uptake, glucose gut absorption, and α-glucosidase inhibition assays. These results may help to explain the bioactivity previously reported for this species and provide information for further study of this species with respect to its potentially antidiabetic properties.
dc.format.mimetypeapplication/pdf
dc.subjectDiabetes
dc.subjectnatural products
dc.subjectpharmacognosy
dc.subjectAlisma orientale
dc.subjectstreptozotocin
dc.subjectalpha-glucosidase inhibition
dc.subjectglucose gut absorption inhibition
dc.subjectglucose uptake induction
dc.subjectisolation
dc.subjectfractionation
dc.subjectnmr
dc.subjectIC50
dc.titleProspecting the Antidiabetic Potential of Alisma orientale
dc.typeThesis
thesis.degree.departmentPharmacognosy
thesis.degree.grantorUniversity of Illinois at Chicago
thesis.degree.levelDoctoral
thesis.degree.namePhD, Doctor of Philosophy
dc.contributor.committeeMemberSoejarto, Djaja
dc.contributor.committeeMemberBrady, Matthew
dc.contributor.committeeMemberDietz, Birgit
dc.contributor.committeeMemberGraham, James
dc.type.materialtext
dc.contributor.chairChe, Chun-Tao


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