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dc.contributor.authorBliwise, Donald L.
dc.contributor.authorHoward, Lauren E.
dc.contributor.authorMoreira, Daniel M.
dc.contributor.authorAndriole, Gerald L.
dc.contributor.authorHopp, Martin L.
dc.contributor.authorFreedland, Stephen J.
dc.descriptionPost print version of article may differ from published version. The final publication is available at; DOI: 10.1038/s41391-018-0090-5en_US
dc.description.abstractImportance: Nocturia (voids arising from sleep) is a ubiquitous phenomenon reflecting many diverse conditions, but whether it has significance in its own right remains uncertain. Objective: To determine whether nocturia is an independent risk factor for mortality Design: Observational study Setting: Global study with most sites in North America and Europe Participants: 7,343 men, ages 50-75 at Baseline from the REDUCE (Reduction by Dutasteride of Prostate Cancer Events) trial Exposures: Nocturia Main Outcome and Measures: Cox proportional hazards models were used to test the association between nocturia (voiding 3 more times per night) and all-cause mortality. Potential confounding variables included: age, race, region of origin, treatment group, self-reported coronary artery disease, diabetes mellitus, hypertension, and peripheral vascular disease, smoking, alcohol use, prostate volume, and diuretics. Self-reported sleep quality, as measured with the Medical Outcomes Study sleep scale, was entered as a final step in the model. Results: Nocturia was associated with increased risk for mortality (Hazard Ratio [HR] = 1.72; 95% CI 1.15-2.55) independent from all demographics and medical comorbidities. Inclusion of disturbed sleep in the model reduced the magnitude of the association (HR = 1.43; 95% CI 0.93-2.19). Conclusions and Relevance: The interruption of sleep by nocturia may have long-term impact on health and may warrant targeted intervention.en_US
dc.publisherSpringer Nature [academic journals on]en_US
dc.rightsAttribution-NonCommercial-NoDerivs 3.0 United States*
dc.titleNocturia and associated mortality: observational data from the REDUCE trialen_US
dc.identifier.citationBliwise, D. L., Howard, L. E., Moreira, D. M., Andriole, G. L., Hopp, M. L., & Freedland, S. J. (2019). Nocturia and associated mortality: observational data from the REDUCE trial. Prostate Cancer and Prostatic Diseases, 22(1), 77-83. doi:10.1038/s41391-018-0090-5en_US

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