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dc.contributor.authorFreitas, Daniel Melecchi de Oliveira
dc.contributor.authorMoreira, Daniel
dc.date.accessioned2019-06-01T03:29:53Z
dc.date.available2019-06-01T03:29:53Z
dc.date.issued2019-04-11
dc.identifier.issn2090-598X
dc.identifier.other10.1080/2090598X.2019.1592636
dc.identifier.urihttp://hdl.handle.net/10027/23467
dc.description.abstractBACKGROUND: Infectious complications are a major concern after trans-rectal ultrasound-guided prostate needle biopsy (TRUS-PNB). Although Fluoroquinolones are currently the first choice, an increase in resistance has raised the question about its recommendation. Fosfomycin trometamol (FMT) is a wide spectrum oral antibiotic with low bacterial resistance reported. Therefore we performed a systematic review and meta-analysis of clinical studies to assess the comparative prophylactic effectiveness of FMT versus Ciprofloxacin (CIP) in subjects who underwent TRUS-PNB. METHODS: A systematic review was performed between January 1970 and June 2017 using Web of Science, Scopus and PubMed databases to identify relevant studies. Preferred Reporting Items for Systematic Reviews and Meta-analysis criteria was used for article selection. Outcomes of interest were febrile and afebrile urinary tract infection (UTI) and the presence of Fluoroquinolone-resistant (FQR) or extended spectrum beta-lactamase (ESBL) producing uropathogens in urinary cultures. RESULTS: Four studies including 2331 subjects were analyzed, 1088 had used FMT and 1243 CIP as antibiotic prophylaxis previous TRSU-PNB. FMT provided a significantly lower afebrile (OR = 0.21, 95%CI = 0.12 – 0.38, P < 0.001) and febrile (OR = 0.15, 95%CI = 0.07 – 0.31, P < 0.001) UTI than CIP. Among all urine cultures, patients in FMT arm also had a significant lower prevalence of FQR and ESBL (E. coli or K. pneumoniae) microorganisms when compared to CIP group (OR = 0.25, 95% CI = 0.12 – 0.21, P = 0.001 and OR = 0.24, 95% CI = 0.10-0.58, P = 0.001, respectively). CONCLUSION: Antibiotic prophylaxis with FMT prior to TRUS-PNB was associated with lower rates of infectious complication when compared to CIP.en_US
dc.language.isoen_USen_US
dc.publisherElsevieren_US
dc.rightsAttribution-NonCommercial-NoDerivs 3.0 United States*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/us/*
dc.subjectFosfomycinen_US
dc.subjectCiprofloxacinen_US
dc.subjectUrinary tract infectionen_US
dc.titleFosfomycin Trometamol versus Ciprofloxacin for antibiotic prophylaxis prior transrectal ultrasound guided prostate biopsy: a meta-analysis of clinical studiesen_US
dc.typeArticleen_US
dc.identifier.citationreitas, D. M. D. O., & Moreira, D. M. (2019). Fosfomycin trometamol vs ciprofloxacin for antibiotic prophylaxis before transrectal ultrasonography-guided prostate biopsy: A meta-analysis of clinical studies. Arab Journal of Urology. doi:10.1080/2090598X.2019.1592636en_US


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