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dc.contributor.authorYuan, Weiping
dc.contributor.authorLeisner, Tina M
dc.contributor.authorMcFadden, Andrew W
dc.contributor.authorWang, Zhengyan
dc.contributor.authorLarson, Mark K
dc.contributor.authorClark, Shantres
dc.contributor.authorBoudignon-Proudhon, Christel
dc.contributor.authorLam, Stephen CT
dc.contributor.authorParise, Leslie V
dc.date.accessioned2009-06-18T18:13:45Z
dc.date.available2009-06-18T18:13:45Z
dc.date.issued2006-01-17
dc.identifier.bibliographicCitationYuan, W. P., T. M. Leisner, A. W. McFadden, Z. Y. Wang, M. K. Larson, S. Clark, C. Boudignon-Proudhon, S. C. T. Lam, and L. V. Parise, 2006, CIB1 is an endogenous inhibitor of agonist-induced integrin alpha IIb beta 3 activation: Journal of Cell Biology, v. 172, no. 2, p. 169-175. http://www.jcb.org.proxy.cc.uic.edu/cgi/content/abstract/172/2/169en
dc.identifier.issn0021-9525
dc.identifier.otherdoi:10.1083/jcb.200505131
dc.identifier.urihttp://hdl.handle.net/10027/5594
dc.descriptionCopyright:http://www.jcb.org/misc/copyright.pdfen
dc.description.abstractIn response to agonist stimulation, the alpha IIb beta 3 integrin on platelets is converted to an active conformation that binds fibrinogen and mediates platelet aggregation. This process contributes to both normal hemostasis and thrombosis. Activation of alpha IIb beta 3 is believed to occur in part via engagement of the beta 3 cytoplasmic tail with talin; however, the role of the alpha IIb tail and its potential binding partners in regulating alpha IIb beta 3 activation is less clear. We report that calcium and integrin binding protein 1 (CIB1), which interacts directly with the alpha IIb tail, is an endogenous inhibitor of alpha IIb beta 3 activation; overexpression of CIB1 in megakaryocytes blocks agonist-induced alpha IIb beta 3 activation, whereas reduction of endogenous CIB1 via RNA interference enhances activation. CIB1 appears to inhibit integrin activation by competing with talin for binding to alpha IIb beta 3, thus providing a model for tightly controlled regulation of alpha IIb beta 3 activation.en
dc.language.isoen_USen
dc.publisherRockefeller University Pressen
dc.subjectCIB1, calcium and integrin binding protein 1en
dc.subjectcytoplasmic domainen
dc.subjectcalcium-binding proteinen
dc.titleCIB1 is an endogenous inhibitor of agonist-induced integrin aIIbb3 [alpha II b beta 3]activationen
dc.typeArticleen


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