Now showing items 2-21 of 39

    • Analysis of YFP(J16)-R6/2 reporter mice and postmortem brains reveals early pathology and increased vulnerability of callosal axons in Huntington's disease. 

      Gatto, RG; Chu, Y.; Ye, AQ; Price, SD; Tavassoli, E.; Buenaventura, A.; Brady, ST; Magin, RL; Kordower, JH; Morfini, GA (Oxford University Press, 2015-09-15)
      Cumulative evidence indicates that the onset and severity of Huntington’s disease (HD) symptoms correlate with connectivity deficits involving specific neuronal populations within cortical and basal ganglia circuits. Brain ...
    • ApoE4 delays dendritic spine formation during neuron development and accelerates loss of mature spines in vitro 

      Nwabuisi-Heath, E.; Rebeck, G.W.; LaDu, M.J.; Yu, C. (Sage Publications, 2014-01-06)
      The ε4 allele of the gene that encodes apolipoprotein E (APOE4) is the greatest genetic risk factor for Alzheimer’s disease (AD), while APOE2 reduces AD risk, compared to APOE3. The mechanism(s) underlying the effects ...
    • APOE4 Induces Site-Specific Tau Phosphorylation Through Calpain-CDK5 Signaling Pathway in EFAD-Tg Mice. 

      Zhou M; Huang T; Collins N; Zhang J; Shen H; Dai X; Xiao N; Wu X; Wei Z; York J; Lin L; Zhu Y; LaDu MJ; Chen X (Bentham Science Publishers, 2016-09)
      APOE4 is the greatest genetic risk factor for Alzheimer's disease (AD), particularly associated with increased levels of amyloid-β (Aβ) and amyloid deposition. However, it remains unclear whether APOE4 is associated with ...
    • APOE4-specific Changes in A beta Accumulation in a New Transgenic Mouse Model of Alzheimer Disease 

      Youmans, Katherine L.; Tai, Leon M.; Nwabuisi-Heath, Evelyn; Jungbauer, Lisa; Kanekiyo, Takahisa; Gan, Ming; Kim, Jungsu; Eimer, William A.; Estus, Steve; Rebeck, G. William; Weeber, Edwin J; Bu, Guojun; Yu, Chunjiang; LaDu, Mary Jo (American Society for Biochemistry and Molecular Biology, 2012-12)
      APOE4 is the greatest risk factor for Alzheimer disease (AD) and synergistic effects with amyloid-beta peptide (A beta) suggest interactions among apoE isoforms and different forms of A beta accumulation. However, it remains ...
    • Apolipoprotein E as a β-amyloid-independent factor in Alzheimer's disease 

      Wolf, Andrew B.; Valla, Jon; Bu, Guojun; Kim, Jungsu; LaDu, Mary Jo; Reiman, Eric M.; Caselli, Richard J. (BioMed Central, 2013)
      APOE, which encodes apolipoprotein E, is the most prevalent and best established genetic risk factor for late-onset Alzheimer’s disease. Current understanding of Alzheimer’s disease pathophysiology posits an important role ...
    • Augmented expression of MYC and/or MYCN protein defines highly aggressive MYC-driven neuroblastoma: a Children’s Oncology Group study 

      Wang, LL; Teshiba, R; Ikegaki, N.; Tang, XX; Naranjo, A; London, WB; Hogarty, MD (Cancer Research UK, 2015-06)
      Background: MYCN amplification with subsequent MYCN protein overexpression is a powerful indicator of poor prognosis of neuroblastoma patients. Little is known regarding the prognostic significance of the homologous MYC ...
    • Aurora kinase A is a possible target of OSU‑03012 to destabilize MYC family proteins 

      Silva, A.; Wang, J.; Lomahan, S.; Tran, T.- A.; Grenlin, L.; Suganami, A.; Tamura, Y.; Ikegaki, N. (Spandidos Publications, 2014-07-11)
      OSU-03012, a 3-phosphoinositide-dependent kinase-1 (PDK1) inhibitor, destabilizes MYCN and MYC proteins in neuroblastoma cells. However, AKT phosphorylation is barely detectable in neuroblastoma cells under normal culture ...
    • Aurora kinase A is a possible target of OSU‑03012 to destabilize MYC family proteins. 

      Silva, A.; Wang, J.; Lomahan, S.; Tran, T.A.; Grenlin, L.; Suganami, A.; Tamura, Y.; Ikegaki, N. (Spandidos Publications, 2014-09)
      OSU-03012, a 3-phosphoinositide-dependent kinase-1 (PDK1) inhibitor, destabilizes MYCN and MYC proteins in neuroblastoma cells. However, AKT phosphorylation is barely detectable in neuroblastoma cells under normal culture ...
    • Axonopathy is a compounding factor in the pathogenesis of Krabbe disease 

      Castelvetri, Ludovico C.; Givogri, Maria I.; Zhu, Hongling; Smith, Benjamin; Lopez-Rosas, Aurora; Qiu, Xi; van Breemen, Richard; Bongarzone, Ernesto (Springer Verlag, 2011-03-04)
      Loss-of-function of the lysosomal enzyme galactosyl-ceramidase (GALC) causes the accumulation of the lipid raft-associated sphingolipid psychosine, the disruption of postnatal myelination, neurodegeneration and early death ...
    • Destabilization of MYC/MYCN by the mitochondrial inhibitors, metaiodobenzylguanidine, metformin and phenformin 

      Wang, Stephanie S; Hsiao, Ruth; Limpar, Mariko M; Lomahan, Sarah; Tran, Tuan-Anh; Maloney, Nolan J; Ikegaki, Naohiko; Tang, Xao X (Spandidos Publications, 2013-11)
      In the present study, we investigated the anticancer effects of the mitochondrial inhibitors, metaiodobenzylguanidine (MIBG), metformin and phenformin. 131I-MIBG has been used for scintigraphic detection and the targeted ...
    • Differential Regulation of Amyloid-β Endocytic Trafficking and Lysosomal Degradation by Apolipoprotein E Isoforms 

      Li, Jie; Kanekiyo, Takahisa; Shinohara, Mitsuru; Zhang, Yunwu; LaDu, Mary Jo; Xu, Huaxi; Bu, Guojun (American Society for Biochemistry and Molecular Biology, 2012-12)
      Aggregation of amyloid-beta (A beta) peptides leads to synaptic disruption and neurodegeneration in Alzheimer disease (AD). A major A beta clearance pathway in the brain is cellular uptake and degradation. However, how A ...
    • EFAD transgenic mice as a human APOE relevant preclinical model of Alzheimer's disease 

      Tai, LM; Balu, D; Avila-Munoz, E; Abdullah, L; Thomas, R; Collins, N; Valencia-Olvera, AC; LaDu, MJ (AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC, 2017-09)
      Identified in 1993, APOE4 is the greatest genetic risk factor for sporadic Alzheimer's disease (AD), increasing risk up to 15-fold compared with APOE3, with APOE2 decreasing AD risk. However, the functional effects of APOE4 ...
    • Effects of eribulin, vincristine, paclitaxel and ixabepilone on fast axonal transport and kinesin-1 driven microtubule gliding: implications for chemotherapy-induced peripheral neuropathy. 

      LaPointe, Nichole E.; Morfini, Gerardo; Brady, Scott T.; Feinstein, Stuart C.; Wilson, Leslie; Jordan, MaryAnn (Elsevier, 2013-07)
      Chemotherapy-induced peripheral neuropathy (CIPN) is a serious, painful and dose-limiting side effect of cancer drugs that target microtubules. The mechanisms underlying the neuronal damage are unknown, but may include ...
    • Endocytic pathways mediating oligomeric Aβ42 neurotoxicity 

      Yu, Chunjiang; Health, Evelyn; Laxton, Kevin; LaDu, Mary Jo (BioMed Central, 2010-05-17)
      Background One pathological hallmark of Alzheimer’s disease (AD) is amyloid plaques, composed primarily of amyloid-β peptide (Aβ). Over-production or diminished clearance of the 42 amino acid form of Aβ (Aβ42) in the brain ...
    • Endocytic pathways mediating oligomeric Aβ42 neurotoxicity 

      Yu, Chunjiang; Nwabuisi-Heath, Evelyn; Laxton, Kevin; LaDu, Mary Jo (BioMed Central, 2010-05-17)
      Background: One pathological hallmark of Alzheimer’s disease (AD) is amyloid plaques, composed primarily of amyloid-β peptide (Aβ). Over-production or diminished clearance of the 42 amino acid form of Aβ (Aβ42) in the ...
    • Evidence for Fibroblast Growth Factor-2 as a Mediator of Amphetamine-Enhanced Motor Improvement following Stroke 

      Wolf, W.A.; Martin, J.L.; Kartje, G.L.; Farrer, R.G. (Public Library of Science, 2014-09-17)
      Previously we have shown that addition of amphetamine to physical therapy results in enhanced motor improvement following stroke in rats, which was associated with the formation of new motor pathways from cortical projection ...
    • Glutamate Transporters EAAT4 and EAAT5 Are Expressed in Vestibular Hair Cells and Calyx Endings 

      Dalet, Antoine; Bonsacquet, Jeremie; Gaboyard-Niay, Sophie; Calin-Jageman, Irina; Chidavaenzi, Robstein L.; Venteo, Stephanie; Desmadryl, Gilles; Goldberg, Jay M.; Lysakowski, Anna; Chabbert, Christian (Public Library of Science, 2012-09)
      Glutamate is the neurotransmitter released from hair cells. Its clearance from the synaptic cleft can shape neurotransmission and prevent excitotoxicity. This may be particularly important in the inner ear and in other ...
    • Inhibition of Fast Axonal Transport by Pathogenic SOD1 Involves Activation of p38 MAP Kinase 

      Morfini, Gerardo A.; Bosco, Daryl A.; Brown, Hannah; Gatto, Rodolfo; Kaminska, Agnieszka; Song, Yuyu; Molla, Linda; Baker, Lisa; Marangoni, M. Natalia; Berth, Sarah; Tavassoli, Ehsan; Bagnato, Carolina; Tiwari, Ashutosh; Hayward, Lawrence J.; Pigino, Gustavo F.; Watterson, D. Martin; Huang, Chun-Fang; Banker, Gary; Brown Jr, Robert H.; Brady, Scott T. (PLoS One, 2013-06)
      Dying-back degeneration of motor neuron axons represents an established feature of familial amyotrophic lateral sclerosis (FALS) associated with superoxide dismutase 1 (SOD1) mutations, but axon-autonomous effects of ...
    • Intraneuronal Aβ detection in 5xFAD mice by a new Aβ-specific antibody 

      Youmans, Katherine L.; Tai, Leon M.; Kanekiyo, Takahisa; Stine Jr, W Blaine; Michon, Sara-Claude; Nwabuisi-Heath, Evelyn; Manelli, Arlene M.; Fu, Yifan; Riordan, Sean; Eimer, William A; Binder, Lester; Bu, Guojun; Yu, Chunjiang; Hartley, Dean M.; LaDu, Mary Jo (BioMed Central, 2012)
      Background: The form(s) of amyloid-b peptide (Ab) associated with the pathology characteristic of Alzheimer’s disease (AD) remains unclear. In particular, the neurotoxicity of intraneuronal Ab accumulation is an issue ...
    • Introducing Human APOE into Aβ Transgenic Mouse Models 

      Tai, Leon M.; Youmans, Katherine L.; Jungbauer, Lisa; Yu, Chunjiang; LaDu, Mary Jo (SAGE-Hindawi Access to Research, 2011)
      Apolipoprotein E (apoE) and apoE/amyloid-β (Aβ) transgenic (Tg) mouse models are critical to understanding apoE-isoform effects on Alzheimer’s disease risk. Compared to wild type, apoE−/− mice exhibit neuronal deficits, ...