Now showing items 9-28 of 39

    • Aurora kinase A is a possible target of OSU‑03012 to destabilize MYC family proteins. 

      Silva, A.; Wang, J.; Lomahan, S.; Tran, T.A.; Grenlin, L.; Suganami, A.; Tamura, Y.; Ikegaki, N. (Spandidos Publications, 2014-09)
      OSU-03012, a 3-phosphoinositide-dependent kinase-1 (PDK1) inhibitor, destabilizes MYCN and MYC proteins in neuroblastoma cells. However, AKT phosphorylation is barely detectable in neuroblastoma cells under normal culture ...
    • Axonopathy is a compounding factor in the pathogenesis of Krabbe disease 

      Castelvetri, Ludovico C.; Givogri, Maria I.; Zhu, Hongling; Smith, Benjamin; Lopez-Rosas, Aurora; Qiu, Xi; van Breemen, Richard; Bongarzone, Ernesto (Springer Verlag, 2011-03-04)
      Loss-of-function of the lysosomal enzyme galactosyl-ceramidase (GALC) causes the accumulation of the lipid raft-associated sphingolipid psychosine, the disruption of postnatal myelination, neurodegeneration and early death ...
    • Destabilization of MYC/MYCN by the mitochondrial inhibitors, metaiodobenzylguanidine, metformin and phenformin 

      Wang, Stephanie S; Hsiao, Ruth; Limpar, Mariko M; Lomahan, Sarah; Tran, Tuan-Anh; Maloney, Nolan J; Ikegaki, Naohiko; Tang, Xao X (Spandidos Publications, 2013-11)
      In the present study, we investigated the anticancer effects of the mitochondrial inhibitors, metaiodobenzylguanidine (MIBG), metformin and phenformin. 131I-MIBG has been used for scintigraphic detection and the targeted ...
    • Differential Regulation of Amyloid-β Endocytic Trafficking and Lysosomal Degradation by Apolipoprotein E Isoforms 

      Li, Jie; Kanekiyo, Takahisa; Shinohara, Mitsuru; Zhang, Yunwu; LaDu, Mary Jo; Xu, Huaxi; Bu, Guojun (American Society for Biochemistry and Molecular Biology, 2012-12)
      Aggregation of amyloid-beta (A beta) peptides leads to synaptic disruption and neurodegeneration in Alzheimer disease (AD). A major A beta clearance pathway in the brain is cellular uptake and degradation. However, how A ...
    • EFAD transgenic mice as a human APOE relevant preclinical model of Alzheimer's disease 

      Tai, LM; Balu, D; Avila-Munoz, E; Abdullah, L; Thomas, R; Collins, N; Valencia-Olvera, AC; LaDu, MJ (AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC, 2017-09)
      Identified in 1993, APOE4 is the greatest genetic risk factor for sporadic Alzheimer's disease (AD), increasing risk up to 15-fold compared with APOE3, with APOE2 decreasing AD risk. However, the functional effects of APOE4 ...
    • Effects of eribulin, vincristine, paclitaxel and ixabepilone on fast axonal transport and kinesin-1 driven microtubule gliding: implications for chemotherapy-induced peripheral neuropathy. 

      LaPointe, Nichole E.; Morfini, Gerardo; Brady, Scott T.; Feinstein, Stuart C.; Wilson, Leslie; Jordan, MaryAnn (Elsevier, 2013-07)
      Chemotherapy-induced peripheral neuropathy (CIPN) is a serious, painful and dose-limiting side effect of cancer drugs that target microtubules. The mechanisms underlying the neuronal damage are unknown, but may include ...
    • Endocytic pathways mediating oligomeric Aβ42 neurotoxicity 

      Yu, Chunjiang; Health, Evelyn; Laxton, Kevin; LaDu, Mary Jo (BioMed Central, 2010-05-17)
      Background One pathological hallmark of Alzheimer’s disease (AD) is amyloid plaques, composed primarily of amyloid-β peptide (Aβ). Over-production or diminished clearance of the 42 amino acid form of Aβ (Aβ42) in the brain ...
    • Endocytic pathways mediating oligomeric Aβ42 neurotoxicity 

      Yu, Chunjiang; Nwabuisi-Heath, Evelyn; Laxton, Kevin; LaDu, Mary Jo (BioMed Central, 2010-05-17)
      Background: One pathological hallmark of Alzheimer’s disease (AD) is amyloid plaques, composed primarily of amyloid-β peptide (Aβ). Over-production or diminished clearance of the 42 amino acid form of Aβ (Aβ42) in the ...
    • Evidence for Fibroblast Growth Factor-2 as a Mediator of Amphetamine-Enhanced Motor Improvement following Stroke 

      Wolf, W.A.; Martin, J.L.; Kartje, G.L.; Farrer, R.G. (Public Library of Science, 2014-09-17)
      Previously we have shown that addition of amphetamine to physical therapy results in enhanced motor improvement following stroke in rats, which was associated with the formation of new motor pathways from cortical projection ...
    • Glutamate Transporters EAAT4 and EAAT5 Are Expressed in Vestibular Hair Cells and Calyx Endings 

      Dalet, Antoine; Bonsacquet, Jeremie; Gaboyard-Niay, Sophie; Calin-Jageman, Irina; Chidavaenzi, Robstein L.; Venteo, Stephanie; Desmadryl, Gilles; Goldberg, Jay M.; Lysakowski, Anna; Chabbert, Christian (Public Library of Science, 2012-09)
      Glutamate is the neurotransmitter released from hair cells. Its clearance from the synaptic cleft can shape neurotransmission and prevent excitotoxicity. This may be particularly important in the inner ear and in other ...
    • Inhibition of Fast Axonal Transport by Pathogenic SOD1 Involves Activation of p38 MAP Kinase 

      Morfini, Gerardo A.; Bosco, Daryl A.; Brown, Hannah; Gatto, Rodolfo; Kaminska, Agnieszka; Song, Yuyu; Molla, Linda; Baker, Lisa; Marangoni, M. Natalia; Berth, Sarah; Tavassoli, Ehsan; Bagnato, Carolina; Tiwari, Ashutosh; Hayward, Lawrence J.; Pigino, Gustavo F.; Watterson, D. Martin; Huang, Chun-Fang; Banker, Gary; Brown Jr, Robert H.; Brady, Scott T. (PLoS One, 2013-06)
      Dying-back degeneration of motor neuron axons represents an established feature of familial amyotrophic lateral sclerosis (FALS) associated with superoxide dismutase 1 (SOD1) mutations, but axon-autonomous effects of ...
    • Intraneuronal Aβ detection in 5xFAD mice by a new Aβ-specific antibody 

      Youmans, Katherine L.; Tai, Leon M.; Kanekiyo, Takahisa; Stine Jr, W Blaine; Michon, Sara-Claude; Nwabuisi-Heath, Evelyn; Manelli, Arlene M.; Fu, Yifan; Riordan, Sean; Eimer, William A; Binder, Lester; Bu, Guojun; Yu, Chunjiang; Hartley, Dean M.; LaDu, Mary Jo (BioMed Central, 2012)
      Background: The form(s) of amyloid-b peptide (Ab) associated with the pathology characteristic of Alzheimer’s disease (AD) remains unclear. In particular, the neurotoxicity of intraneuronal Ab accumulation is an issue ...
    • Introducing Human APOE into Aβ Transgenic Mouse Models 

      Tai, Leon M.; Youmans, Katherine L.; Jungbauer, Lisa; Yu, Chunjiang; LaDu, Mary Jo (SAGE-Hindawi Access to Research, 2011)
      Apolipoprotein E (apoE) and apoE/amyloid-β (Aβ) transgenic (Tg) mouse models are critical to understanding apoE-isoform effects on Alzheimer’s disease risk. Compared to wild type, apoE−/− mice exhibit neuronal deficits, ...
    • Levels of soluble apolipoprotein E/amyloid-β complex are reduced and oligomeric Aβ increased with APOE4 and Alzheimer disease in a transgenic mouse model and human samples 

      Tai, Leon M.; Bilousova, Tina; Jungbauer, Lisa; Roeske, Stephen K.; Youmans, Katherine L.; Yu, Chunjiang; Poon, Wayne W.; Cornwell, Lindsey B.; Miller, Carol A.; Vinters, Harry V.; Van Eldik, Linda J.; Fardo, David W.; Estus, Steve; Bu, Guojun; Gylys, Karen Hoppens; LaDu, Mary Jo (American Society for Biochemistry and Molecular Biology, 2013-02)
      Human apolipoprotein E (apoE) isoforms may differentially modulate amyloid-β (Aβ) levels. Evidence suggests physical interactions between apoE and Aβ are partially responsible for these functional effects. However, the ...
    • Levels of soluble apolipoprotein E/amyloid-β complex are reduced and oligomeric Aβ increased with APOE4 and Alzheimer disease in a transgenic mouse model and human samples 

      Tai, Leon M.; Bilousova, Tina; Jungbauer, Lisa; Roeske, Stephen K.; Youmans, Katherine L.; Yu, Chunjiang; Poon, Wayne W.; Cornwell, Lindsey B.; Miller, Carol A.; Vinters, Harry V.; Van Eldik, Linda J.; Fardo, David W.; Estus, Steve; Bu, Guojun; Gylys, Karen Hoppens; LaDu, Mary Jo (Journal of Biological Chemistry, 2013-02-22)
      Human apolipoprotein E (apoE) isoforms may differentially modulate amyloid-β (Aβ) levels. Evidence suggests physical interactions between apoE and Aβ are partially responsible for these functional effects. However, the ...
    • Long-term Motor Improvement After Stroke is Enhanced by Short-term Treatment With the Alpha2 Antagonist, Atipamezole 

      Beltran, Erik J.; Papadopoulos, Catherine M.; Tsai, Shih-Yen; Kartje, Gwendolyn L.; Wolf, William A. (Elsevier, 2010-07)
      Drugs that increase central noradrenergic activity have been shown to enhance the rate of recovery of motor function in preclinical models of brain damage. Less is known about whether noradrenergic agents can improve the ...
    • Merlin Modulates Microtubule-Based Vesicle Trafficking via Rac, MLK and p38 

      Hennigan, Robert F.; Moon, Chandra A.; Parysek, Linda M.; Monk, Kelly R.; Morfini, Gerardo; Berth, Sarah; Brady, Scott; Ratner, Nancy (Nature Publishing Group, 2013-02)
      Neurofibromatosis type 2 patients develop schwannomas, meningiomas and ependymomas resulting from mutations in the tumor suppressor gene, NF2, encoding a membrane-cytoskeleton adapter protein called merlin. Merlin regulates ...
    • Molecular Mechanisms of Environmental Enrichment: Impairments in Akt/GSK3b, Neurotrophin-3 and CREB Signaling 

      Hu, Yuan-Shih; Long, Nancy; Pigino, Gustavo; Brady, Scott T.; Lazarov, Orly (PLoS One, 2013-05)
      Experience of mice in a complex environment enhances neurogenesis and synaptic plasticity in the hippocampus of wild type and transgenic mice harboring familial Alzheimer’s disease (FAD)-linked APPswe/PS1DE9. In FAD mice, ...
    • Molecular Microdomains in a Sensory Terminal, the Vestibular Calyx Ending 

      Lysakowski, Anna; Gaboyard-Niay, Sophie; Calin-Jageman, Irina; Chatlani, Shilpa; Price, Steven D.; Eatock, Ruth Anne (Society for Neuroscience, 2011-07-06)
      Many primary vestibular afferents form large cup-shaped postsynaptic terminals (calyces) that envelope the basolateral surfaces of type I hair cells. The calyceal terminals both respond to glutamate released from ribbon ...
    • Nature in corrosion-erosion surface for [TiN/TiAlN]n nanometric multilayers growth on AISI 1045 steel 

      Caicedo, J. C.; Cabrera, G.; Caicedo, H. H.; Amaya, C.; Aperador, W. (Elsevier, 2012-04)
      The aim of this work is to characterize the electrochemical behavior of [TiN/TiAlN]n multilayer coatings under corrosion-erosion condition. The multilayers with bilayer numbers (n) of 2, 6, 12, and 24 and/or bilayer period ...