Now showing items 1-5 of 5
Of mice and men: neurogenesis, cognition, and Alzheimer's disease
Neural stem cells are maintained in the subgranular layer of the dentate gyrus and in the subventricular zone in the adult mammalian brain throughout life. Neurogenesis is continuous, but its extent is tightly regulated ...
All in the family: how the APPs regulate neurogenesis
Recent intriguing evidence suggests that metabolites of amyloid precursor protein(APP), mutated in familial forms of Alzheimer’s disease(AD), play critical roles indevelopmental and post natal neurogenesis. Of note is ...
Presenilin-1 Regulates Neural Progenitor Cell Differentiation in the Adult Brain
(Society for Neuroscience, 2011-02)
Presenilin-1 (PS1) is the catalytic core of the aspartyl protease γ-secretase. Previous genetic studies using germ-line deletion of PS1 and conditional knock-out mice demonstrated that PS1 plays an essential role in neuronal ...
Molecular Mechanisms of Environmental Enrichment: Impairments in Akt/GSK3b, Neurotrophin-3 and CREB Signaling
(PLoS One, 2013-05)
Experience of mice in a complex environment enhances neurogenesis and synaptic plasticity in the hippocampus of wild type and transgenic mice harboring familial Alzheimer’s disease (FAD)-linked APPswe/PS1DE9. In FAD mice, ...
Soluble amyloid precursor protein: a novel proliferation factor of adult progenitor cells of ectodermal and mesodermal origin
(BioMed Central, 2011-08)
Introduction: Soluble amyloid precursor protein a (sAPPa) is a proteolyte of APP cleavage by a-secretase. The significance of the cleavage and the physiological role of sAPPa are unknown. A crystal structure of a region ...