Now showing items 1-4 of 4
The Sphingolipid Psychosine Inhibits Fast Axonal Transport in Krabbe Disease by Activation of GSK3 and Deregulation of Molecular Motors
(Society for Neuroscience, 2013-06)
Loss of function of galactosylceramidase lysosomal activity causes demyelination and vulnerability of various neuronal populations in Krabbe disease. Psychosine, a lipid-raft-associated sphingolipid that accumulates in ...
Molecular Mechanisms of Environmental Enrichment: Impairments in Akt/GSK3b, Neurotrophin-3 and CREB Signaling
(PLoS One, 2013-05)
Experience of mice in a complex environment enhances neurogenesis and synaptic plasticity in the hippocampus of wild type and transgenic mice harboring familial Alzheimer’s disease (FAD)-linked APPswe/PS1DE9. In FAD mice, ...
Pathogenic Forms of Tau Inhibit Kinesin-Dependent Axonal Transport Through a Tau-Dependent Mechanism Involving Activation of Axonal Phosphotransferases
(Society for Neuroscience, 2011-07)
Aggregated filamentous forms of hyperphosphorylated tau (a microtubule-associated protein) represent pathological hallmarks of Alzheimer’s disease (AD) and other tauopathies. While axonal transport dysfunction is thought ...
Conventional kinesin: Biochemical heterogeneity and functional implications in health and disease
(Elsevier Inc., 2016-06-18)
Intracellular trafficking events powered by microtubule-based molecular motors facilitate the targeted delivery of selected molecular components to specific neuronal subdomains. Within this context, we provide a brief ...