Now showing items 1-2 of 2
Phosphoregulation of Tau modulates inhibition of kinesin-1 motility
(American Society for Cell Biology, 2017-04-15)
Microtubule-based axonal transport is tightly regulated by numerous pathways, ensuring appropriate delivery of specific organelle cargoes to selected subcellular domains. Highlighting the importance of this process, ...
EFAD transgenic mice as a human APOE relevant preclinical model of Alzheimer's disease
(AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC, 2017-09)
Identified in 1993, APOE4 is the greatest genetic risk factor for sporadic Alzheimer's disease (AD), increasing risk up to 15-fold compared with APOE3, with APOE2 decreasing AD risk. However, the functional effects of APOE4 ...