Now showing items 1-5 of 5
Differential Regulation of Amyloid-β Endocytic Trafficking and Lysosomal Degradation by Apolipoprotein E Isoforms
(American Society for Biochemistry and Molecular Biology, 2012-12)
Aggregation of amyloid-beta (A beta) peptides leads to synaptic disruption and neurodegeneration in Alzheimer disease (AD). A major A beta clearance pathway in the brain is cellular uptake and degradation. However, how A ...
Levels of soluble apolipoprotein E/amyloid-β complex are reduced and oligomeric Aβ increased with APOE4 and Alzheimer disease in a transgenic mouse model and human samples
(Journal of Biological Chemistry, 2013-02-22)
Human apolipoprotein E (apoE) isoforms may differentially modulate amyloid-β (Aβ) levels. Evidence suggests physical interactions between apoE and Aβ are partially responsible for these functional effects. However, the ...
Intraneuronal Aβ detection in 5xFAD mice by a new Aβ-specific antibody
(BioMed Central, 2012)
Background: The form(s) of amyloid-b peptide (Ab) associated with the pathology characteristic of Alzheimer’s disease (AD) remains unclear. In particular, the neurotoxicity of intraneuronal Ab accumulation is an issue ...
ApoE4 delays dendritic spine formation during neuron development and accelerates loss of mature spines in vitro
(Sage Publications, 2014-01-06)
The ε4 allele of the gene that encodes apolipoprotein E (APOE4) is the greatest genetic risk factor for Alzheimer’s disease (AD), while APOE2 reduces AD risk, compared to APOE3. The mechanism(s) underlying the effects ...
APOE4 Induces Site-Specific Tau Phosphorylation Through Calpain-CDK5 Signaling Pathway in EFAD-Tg Mice.
(Bentham Science Publishers, 2016-09)
APOE4 is the greatest genetic risk factor for Alzheimer's disease (AD), particularly associated with increased levels of amyloid-β (Aβ) and amyloid deposition. However, it remains unclear whether APOE4 is associated with ...