Now showing items 1-3 of 3
Levels of soluble apolipoprotein E/amyloid-β complex are reduced and oligomeric Aβ increased with APOE4 and Alzheimer disease in a transgenic mouse model and human samples
(American Society for Biochemistry and Molecular Biology, 2013-02)
Human apolipoprotein E (apoE) isoforms may differentially modulate amyloid-β (Aβ) levels. Evidence suggests physical interactions between apoE and Aβ are partially responsible for these functional effects. However, the ...
ApoE4 delays dendritic spine formation during neuron development and accelerates loss of mature spines in vitro
(Sage Publications, 2014-01-06)
The ε4 allele of the gene that encodes apolipoprotein E (APOE4) is the greatest genetic risk factor for Alzheimer’s disease (AD), while APOE2 reduces AD risk, compared to APOE3. The mechanism(s) underlying the effects ...
EFAD transgenic mice as a human APOE relevant preclinical model of Alzheimer's disease
(AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC, 2017-09)
Identified in 1993, APOE4 is the greatest genetic risk factor for sporadic Alzheimer's disease (AD), increasing risk up to 15-fold compared with APOE3, with APOE2 decreasing AD risk. However, the functional effects of APOE4 ...