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    • Axonopathy is a compounding factor in the pathogenesis of Krabbe disease 

      Castelvetri, Ludovico C.; Givogri, Maria I.; Zhu, Hongling; Smith, Benjamin; Lopez-Rosas, Aurora; Qiu, Xi; van Breemen, Richard; Bongarzone, Ernesto (Springer Verlag, 2011-03-04)
      Loss-of-function of the lysosomal enzyme galactosyl-ceramidase (GALC) causes the accumulation of the lipid raft-associated sphingolipid psychosine, the disruption of postnatal myelination, neurodegeneration and early death ...